{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:26:53Z","timestamp":1792272413776,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Peripheral neuropathy is a frequent complication of brentuximab vedotin (BV), used in CD30+ lymphoma treatment. Classic BV\u2010induced neuropathy (BV\u2010CN) is a mild distal sensory axonal polyneuropathy. Severe BV\u2010induced inflammatory neuropathies (BV\u2010IN) have been described. BV\u2010IN contribute to lymphoma\u2010associated morbidity but might be immunotherapy\u2010responsive. Our primary objective was to evaluate the rate of BV\u2010IN. Our secondary objectives were to determine risk factors and warning signs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study on all patients treated with BV at our center between April 2014 and September 2021. Clinical, biological, and electrophysiological data were collected. BV\u2010induced neuropathy was defined as the occurrence of neuropathy up to 3\u2009months after BV discontinuation. BV\u2010IN was defined with criteria adapted from European Academy of Neurology\/Peripheral Nerve Society 2021 electrodiagnostic criteria for chronic inflammatory demyelinating polyradiculoneuropathy. Other neuropathies were classified as BV\u2010CN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 83 patients, 41 (49%) developed neuropathy: 35 BV\u2010CN and 6 BV\u2010IN. Thus, the rate of BV\u2010IN was 7.2%. Compared to patients with BV\u2010CN, no predisposing factor was identified. However, patients with BV\u2010IN more frequently presented muscle weakness (67% vs. 5.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), gait disorders (83% vs. 20%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), or acute or subacute onset (67% vs. 14%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). BV\u2010IN was frequently more severe (Common Terminology Criteria for Adverse Events grade \u22653; 50% vs. 0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Four patients were treated with immunotherapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Brentuximab vedotin\u2010induced neuropathy is an overlooked complication. Based on four easily identifiable \u201cred flags\u201d, we provide an algorithm to help non\u2010neurologist physicians that care for BV\u2010treated patients to detect BV\u2010IN. The aim of the algorithm is to decrease the diagnostic and management delay of this disabling neuropathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.16285","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T08:40:43Z","timestamp":1711010443000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Rate and characteristics of inflammatory neuropathies associated with brentuximab vedotin therapy"],"prefix":"10.1111","volume":"31","author":[{"given":"Arthur","family":"Matthys","sequence":"first","affiliation":[{"name":"Department of Neurology AP\u2010HP, Henri Mondor University Hospital  Cr\u00e9teil France"},{"name":"Center for Interdisciplinary Research in Biology, Coll\u00e8ge de France, CNRS UMR 7241, INSERM U1050, Labex Memolife PSL Research University  Paris 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France"},{"name":"Reference Center for Neuromuscular Diseases Nord\/Est\/Ile\u2010de\u2010France  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarik","family":"Nordine","sequence":"additional","affiliation":[{"name":"Unit of Clinical Neurophysiology AP\u2010HP, Henri Mondor University Hospital  Cr\u00e9teil France"},{"name":"Reference Center for Neuromuscular Diseases Nord\/Est\/Ile\u2010de\u2010France  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Gounot","sequence":"additional","affiliation":[{"name":"Lymphoid Malignancies Unit AP\u2010HP, Henri Mondor University Hospital  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Ingen\u2010Housz\u2010Oro","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Paris\u2010Est Cr\u00e9teil University EpiDermE AP\u2010HP, Henri Mondor University Hospital  Cr\u00e9teil 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