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A clinical staging system is lacking for the evolution of AD\u2010associated communication difficulties that could guide diagnosis and care planning. Our aim was to create a symptom\u2010based staging scheme for lvPPA, identifying functional milestones relevant to the broader AD spectrum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An international lvPPA caregiver cohort was surveyed on symptom development under an \u2018exploratory\u2019 survey (34 UK caregivers). Feedback from this survey informed the development of a \u2018consolidation\u2019 survey (27 UK, 10 Australian caregivers) in which caregivers were presented with six provisional clinical stages and feedback was analysed using a mixed\u2010methods approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six clinical stages were endorsed. Early symptoms included word\u2010finding difficulty, with loss of message comprehension and speech intelligibility signalling later\u2010stage progression. Additionally, problems with hearing in noise, memory and route\u2010finding were prominent early non\u2010verbal symptoms. \u2018Milestone\u2019 symptoms were identified that anticipate daily\u2010life functional transitions and care needs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This work introduces a new symptom\u2010based staging scheme for lvPPA, and highlights milestone symptoms that could inform future clinical scales for anticipating and managing communication dysfunction across the AD spectrum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.16304","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T09:03:23Z","timestamp":1714122203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Symptom\u2010based staging for logopenic variant primary progressive aphasia"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4900-6492","authenticated-orcid":false,"given":"Chris J. 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