{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:40:02Z","timestamp":1790278802962,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","award":["IISR\u20102019\u2010104354"],"award-info":[{"award-number":["IISR\u20102019\u2010104354"]}],"id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate whether ongoing axonal loss can be prevented in multifocal motor neuropathy (MMN) treated with immunoglobulin G (IgG), a group of patients with a median disease duration of 15.7\u2009years (range: 8.3\u201337.8), treated with titrated dosages of immunoglobulins, was studied electrophysiologically at time of diagnosis and at follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At follow\u2010up, the Z\u2010score of the compound motor action potential amplitude of the median, fibular, and tibial nerves and the neurological performances were determined. In seven patients with a treatment\u2010free period of 0.3\u2009years (0.2\u20130.4), there was no progression of axonal loss (<jats:italic>p<\/jats:italic>\u2009=\u20090.2), whereas a trend toward further axonal loss by 1.3 Z\u2010scores (0.9\u201317.0, <jats:italic>p<\/jats:italic>\u2009=\u20090.06) was observed in five patients with a treatment\u2010free period of 4.0\u2009years (0.9\u20139.0). The axonal loss in the group with a short treatment delay was significantly smaller than in the group with a longer treatment delay (<jats:italic>p<\/jats:italic>\u2009=\u20090.02). Also, there was an association between treatment delay and ongoing axonal loss (<jats:italic>p<\/jats:italic>\u2009=\u20090.004). The electrophysiological findings at follow\u2010up were associated with the isokinetic strength performance, the neurological impairment score, and the disability, supporting the clinical relevance of the electrophysiological estimate of axonal loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Swift initiation of an immediately titrated IgG dosage can prevent further axonal loss and disability in continuously treated MMN patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16305","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T09:25:12Z","timestamp":1713864312000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prevention of axonal loss after immediate dosage titration of immunoglobulin in multifocal motor neuropathy"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1922-7542","authenticated-orcid":false,"given":"Ali","family":"Al\u2010Zuhairy","sequence":"first","affiliation":[{"name":"Department of Neurology Copenhagen University Hospital (Rigshospitalet)  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Jakobsen","sequence":"additional","affiliation":[{"name":"Department of Neurology Copenhagen University Hospital (Rigshospitalet)  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Krarup","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Neuroscience University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2010.00290.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285615575269"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S39592"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.175"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg019"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.064816"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf193"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000110185.23464.A1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000140497.85952.FA"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2008.00179.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-011-1975-3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.1.229"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12141"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420318"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.12.017"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27722"},{"key":"e_1_2_9_18_1","volume-title":"Electromyography \u2013 Sensory and Motor Conduction. 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