{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:49:04Z","timestamp":1790815744719,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The use of multiple tests, including spirometry, arterial blood gas (ABG) analysis and overnight oximetry (OvOx), is highly recommended to monitor the respiratory function of patients with motor neuron disease (MND). In this study, we propose a composite score to simplify the respiratory management of MND patients and better stratify their prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We screened the clinical charts of 471 non\u2010ventilated MND patients referred to the Neuro\u2010rehabilitation Unit of the San Raffaele Scientific Institute of Milan (January 2001\u2013December 2019), collecting spirometric, ABG and OvOx parameters. To evaluate the prognostic role of each measurement, univariate Cox regression for death\/tracheostomy was performed, and the variables associated with survival were selected to design a scoring system. Univariate and multivariate Cox regression analyses were then carried out to evaluate the prognostic role of the score. Finally, results were replicated in an independent cohort from the Turin ALS Center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population included 450 patients. Six measurements were found to be significantly associated with survival and were selected to design a scoring system (maximum score\u2009=\u20098 points). Kaplan\u2013Meier analysis showed significant stratification of survival and time to non\u2010invasive mechanical ventilation adaptation according to score values, and multivariate analysis confirmed the independent effect of the respiratory score on survival of each cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Forced vital capacity, ABG and OvOx parameters provide complementary information for the respiratory management and prognosis of MND patients and the combination of these parameters into a single score might help neurologists predict prognosis and guide decisions on the timing of the implementation of different diagnostic or therapeutic approaches.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16316","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T10:10:15Z","timestamp":1715163015000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Use of the combination of spirometry, arterial blood gas analysis and overnight oximetry to predict the outcomes of patients affected by motor neuron disease: The <scp>Milan\u2010Torin<\/scp> respiratory score (<scp>Mi\u2010To\u2010RS<\/scp>)"],"prefix":"10.1111","volume":"31","author":[{"given":"Paride","family":"Schito","sequence":"first","affiliation":[{"name":"Neurorehabilitation, Neurology Unit and Neurophysiology Unit San Raffaele Scientific Institute  Milan Italy"},{"name":"Experimental Neuropathology Unit, Division of Neuroscience, Institute of Experimental Neurology (INSPE) San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9995-8133","authenticated-orcid":false,"given":"Umberto","family":"Manera","sequence":"additional","affiliation":[{"name":"\u201cRita Levi Montalcini\u201d Department of Neuroscience, ALS Centre University of Turin  Torino 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