{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:25:44Z","timestamp":1761582344969,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["16\/81\/01"],"award-info":[{"award-number":["16\/81\/01"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000406","name":"Motor Neurone Disease Association","doi-asserted-by":"publisher","award":["Gould\/Jul17\/936\u2010794"],"award-info":[{"award-number":["Gould\/Jul17\/936\u2010794"]}],"id":[{"id":"10.13039\/501100000406","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Given the degenerative nature of the condition, people living with motor neuron disease (MND) experience high levels of psychological distress. The purpose of this research was to investigate the cost\u2010effectiveness of acceptance and commitment therapy (ACT), adapted for the specific needs of this population, for improving quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A trial\u2010based cost\u2013utility analysis over a 9\u2010month period was conducted comparing ACT plus usual care (<jats:italic>n<\/jats:italic>\u2009=\u200997) versus usual care alone (<jats:italic>n<\/jats:italic>\u2009=\u200994) from the perspective of the National Health Service. In the primary analysis, quality\u2010adjusted life years (QALYs) were computed using health utilities generated from the EQ\u20105D\u20105L questionnaire. Sensitivity analyses and subgroup analyses were also carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Difference in costs was statistically significant between the two arms, driven mainly by the intervention costs. Effects measured by EQ\u20105D\u20105L were not statistically significantly different between the two arms. The incremental cost\u2010effectiveness was above the \u00a320,000 to \u00a330,000 per QALY gained threshold used in the UK. However, the difference in effects was statistically significant when measured by the McGill Quality of Life\u2010Revised (MQOL\u2010R) questionnaire. The intervention was cost\u2010effective in a subgroup experiencing medium deterioration in motor neuron symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite the intervention being cost\u2010ineffective in the primary analysis, the significant difference in the effects measured by MQOL\u2010R, the low costs of the intervention, the results in the subgroup analysis, and the fact that ACT was shown to improve the quality of life for people living with MND, suggest that ACT could be incorporated into MND clinical services.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16317","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T10:24:59Z","timestamp":1714040699000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cost\u2010effectiveness of acceptance and commitment therapy for people living with motor neuron disease, and their health\u2010related quality of life"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8889-6806","authenticated-orcid":false,"given":"Anju D.","family":"Keetharuth","sequence":"first","affiliation":[{"name":"School of Medicine and Population Health, Sheffield Centre for Health and Related Research University of Sheffield  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca L.","family":"Gould","sequence":"additional","affiliation":[{"name":"Division of Psychiatry University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"McDermott","sequence":"additional","affiliation":[{"name":"Sheffield Institute for Translational Neuroscience University of Sheffield  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin J.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit, Sheffield Centre for Health and Related Research University of Sheffield  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Rawlinson","sequence":"additional","affiliation":[{"name":"Division of Psychiatry University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Bradburn","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit, Sheffield Centre for Health and Related Research University of Sheffield  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt","family":"Bursnall","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit, Sheffield Centre for Health and Related Research University of Sheffield  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavithra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit, Sheffield Centre for Health and Related Research University of Sheffield  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily J.","family":"Turton","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit, Sheffield Centre for Health and Related Research University of Sheffield  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Tappenden","sequence":"additional","affiliation":[{"name":"School of Medicine and Population Health, Sheffield Centre for Health and Related Research University of Sheffield  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"White","sequence":"additional","affiliation":[{"name":"School of Medicine and Population Health, Sheffield Centre for Health and Related Research University of Sheffield  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Howard","sequence":"additional","affiliation":[{"name":"Division of Psychiatry University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc A.","family":"Serfaty","sequence":"additional","affiliation":[{"name":"Division of Psychiatry University College London  London UK"},{"name":"Priory Hospital North London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance M.","family":"McCracken","sequence":"additional","affiliation":[{"name":"Department of Psychology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher D.","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences &amp; 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