{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:00:37Z","timestamp":1773388837537,"version":"3.50.1"},"reference-count":6,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030_173153"],"award-info":[{"award-number":["320030_173153"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006388","name":"H\u00f4pitaux Universitaires de Gen\u00e8ve","doi-asserted-by":"publisher","award":["PRD 11\u2010I\u20103"],"award-info":[{"award-number":["PRD 11\u2010I\u20103"]}],"id":[{"id":"10.13039\/501100006388","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006388","name":"H\u00f4pitaux Universitaires de Gen\u00e8ve","doi-asserted-by":"publisher","award":["PRD 12\u20102013\u2010I"],"award-info":[{"award-number":["PRD 12\u20102013\u2010I"]}],"id":[{"id":"10.13039\/501100006388","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Idiopathic normal pressure hydrocephalus (iNPH) is a chronic neurological disease resulting in progressive gait and cognitive disorders. We investigated whether the gait phenotype is associated with the severity of cognitive deficits in iNPH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study recruited 88 patients (mean age\u2009=\u200976.18\u2009\u00b1\u20097.21\u2009years, 42% female). Patients were initially referred for suspicion of iNPH and underwent a comprehensive analysis, including gait analysis and cognitive evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this cohort (27% normal gait, 25% frontal gait, 16% parkinsonian gait, 27% other gait abnormalities), patients with parkinsonian and frontal gait had the lowest Mini\u2010Mental State Examination (MMSE) scores and the slowest gait speed. Patients with normal gait had the highest MMSE scores and gait speed. Frontal gait was associated with lower MMSE score, even after adjusting for age, gender, comorbidities, white matter lesions, and education level (<jats:italic>\u03b2<\/jats:italic> = \u22120.221 [95% confidence interval (CI) = \u22123.718 to \u22120.150], <jats:italic>p<\/jats:italic>\u2009=\u20090.034). Normal gait was associated with the best MMSE scores, even after adjusting for the abovementioned variables (<jats:italic>\u03b2<\/jats:italic> =\u20090.231 [95% CI\u2009=\u20090.124\u20133.639], <jats:italic>p<\/jats:italic>\u2009=\u20090.036).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gait phenotypes among iNPH patients are linked to global cognition as assessed with MMSE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16328","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T05:38:47Z","timestamp":1715233127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Normal pressure hydrocephalus and cognitive impairment: The gait phenotype matters too"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0219-2723","authenticated-orcid":false,"given":"Eric","family":"Morel","sequence":"first","affiliation":[{"name":"Department of Neurology University Clinic of Neurology, Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"},{"name":"Faculty of Medicine University of Geneva  Geneva Switzerland"},{"name":"Leenaards Memory Centre, Department of Clinical Neurosciences Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alma","family":"Lingenberg","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Geneva  Geneva Switzerland"},{"name":"Division of Neurology, Department of Clinical Neurosciences Geneva University Hospitals  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9144-4982","authenticated-orcid":false,"given":"St\u00e9phane","family":"Armand","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Geneva  Geneva Switzerland"},{"name":"Willy Taillard Laboratory of Kinesiology Geneva University Hospitals  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0999-1034","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Assal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Geneva  Geneva Switzerland"},{"name":"Division of Neurology, Department of Clinical Neurosciences Geneva University Hospitals  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4455-6719","authenticated-orcid":false,"given":"Gilles","family":"Allali","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Geneva  Geneva Switzerland"},{"name":"Leenaards Memory Centre, Department of Clinical Neurosciences Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"},{"name":"Department of Neurology Albert Einstein College of Medicine, Yeshiva University  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000168185.29659.c5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-020-02270-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020441"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000306100.83882.81"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acs002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4847"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.16328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T06:58:06Z","timestamp":1720249086000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.16328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,8]]},"references-count":6,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/ene.16328"],"URL":"https:\/\/doi.org\/10.1111\/ene.16328","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,8]]},"assertion":[{"value":"2024-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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