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Here, diffusion tensor imaging was used to verify the disruption of the neocortex\u2013cerebellum circuit in spinocerebellar ataxia type 3 (SCA3), and the circuit's disruption correlation with SCA3 motor dysfunction was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 45 patients with familial SCA3, aged 17\u201367\u2009years, and 49 age\u2010 and sex\u2010matched healthy controls, aged 21\u201364\u2009years. Tract\u2010based spatial statistics and probabilistic tractography was conducted using magnetic resonance images of the patients and controls. The correlation between the local probability of probabilistic tractography traced from the cerebellum and clinical symptoms measured using specified symptom scales was also calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cerebellum\u2010originated probabilistic tractography analysis showed that structural connectivity, mainly in the subcortical cerebellar\u2013thalamo\u2013cortical tract, was significantly reduced and the cortico\u2013ponto\u2013cerebellar tract was significantly stronger in the SCA3 group than in the control group. The enhanced tract was extended to the right lateral parietal region and the right primary motor cortex. The enhanced neocortex\u2013cerebellum connections were highly associated with disease progression, including duration and symptomatic deterioration. Tractography probabilities from the cerebellar to parietal and sensorimotor areas were significantly negatively correlated with motor abilities in patients with SCA3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To our knowledge, this study is the first to reveal that disrupting the neocortex\u2013cerebellum loop can cause SCA3\u2010induced motor dysfunctions. The specific interaction between the cerebellar\u2013thalamo\u2013cortical and cortico\u2013ponto\u2013cerebellar pathways in patients with SCA3 and its relationship with ataxia symptoms provides a new direction for future research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16368","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T07:46:07Z","timestamp":1719215167000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Imbalanced optimal feedback motor control system in spinocerebellar ataxia type 3"],"prefix":"10.1111","volume":"31","author":[{"given":"Leinian","family":"Li","sequence":"first","affiliation":[{"name":"7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital Army Medical University (Third Military Medical University)  Chongqing China"},{"name":"School of Psychology Shandong Normal University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LiHua","family":"Deng","sequence":"additional","affiliation":[{"name":"7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YongHua","family":"Huang","sequence":"additional","affiliation":[{"name":"7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YuHan","family":"Zhang","sequence":"additional","affiliation":[{"name":"7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YueYuan","family":"Luo","sequence":"additional","affiliation":[{"name":"7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PeiLing","family":"Ou","sequence":"additional","affiliation":[{"name":"7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LinFeng","family":"Shi","sequence":"additional","affiliation":[{"name":"7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LiMeng","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, College of Basic Medical Science Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"MR Research Collaboration Team Siemens Healthineers Ltd.  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