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This study aimed to measure adherence to secondary prevention medications during 3\u2009years post\u2010ischemic stroke\/transient ischemic attack, using prescription and dispensing data, and identify factors associated with suboptimal adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter, prospective, cohort study involved patients from the STROKE 69 cohort, which included all consecutive patients with suspected acute stroke admitted between November 2015 and December 2016 to any emergency department or stroke center in the Rh\u00f4ne area in France. Prescription data for antihypertensive agents, antidiabetic agents, lipid\u2010lowering drugs, and antithrombotics were collected. Dispensing data were provided by the French regional reimbursement database. Adherence was calculated using the continuous medication acquisition index. Associations between suboptimal adherence and potential influencing factors across the World Health Organization's five dimensions were explored through univariate and multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 1512 eligible patients, 365 were included. Optimal adherence to overall treatment (\u226590%) was observed in 61%, 62%, and 65% of patients in the first, second, and third years, respectively. Education level (high school diploma or higher: OR\u2009=\u20093.24, 95% CI [1.49; 7.36]) and depression (Hospital Anxiety and Depression Scale\u2013Depression scores 8\u201310: OR\u2009=\u20091.90, 95% CI [1.05; 3.44]) were significantly associated with suboptimal adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall adherence to secondary prevention medications was fairly good. Having an initial diagnosis of transient ischemic attack, a high level of education, or depression was associated with increased odds of suboptimal adherence, while having a history of heart rhythm disorder was associated with lower odds.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16395","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T09:44:21Z","timestamp":1719913461000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Determinants of adherence to post\u2010stroke\/transient ischemic attack secondary prevention medications: A cohort study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0175-4819","authenticated-orcid":false,"given":"Damien","family":"Hoarau","sequence":"first","affiliation":[{"name":"Research on Healthcare Performance RESHAPE, INSERM U1290 Universit\u00e9 Claude Bernard Lyon 1  Lyon France"},{"name":"Hospices Civils de Lyon 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