{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T05:28:46Z","timestamp":1781674126618,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["10430012010009"],"award-info":[{"award-number":["10430012010009"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>There are concerns for safety regarding SARS\u2010CoV\u20102 vaccines for patients with autoimmune neuromuscular disease. We compared daily functioning using disease\u2010specific patient\u2010reported outcome measures (PROMs) before and after SARS\u2010CoV\u20102 vaccinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this substudy of a prospective observational cohort study (Target\u2010to\u2010B!), patients with myasthenia gravis (MG), chronic inflammatory demyelinating polyneuropathy (CIDP), multifocal motor neuropathy (MMN), and idiopathic inflammatory myopathy (IIM) vaccinated against SARS\u2010CoV\u20102 were included. Surveys of daily functioning (Myasthenia Gravis Activities of Daily Living, Inflammatory Rasch\u2010Built Overall Disability Scale, Multifocal Motor Neuropathy Rasch\u2010Built Overall Disability Scale, and Health Assessment Questionnaire\u2013Disability Index) were sent before first vaccination and every 60\u2009days thereafter for up to 12\u2009months. Regression models were constructed to assess differences in PROM scores related to vaccination, compared to scores unrelated to vaccination. We also assessed the proportion of patients with deterioration of at least the minimal clinically important difference (MCID) between before first vaccination and 60\u2009days thereafter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 325 patients (median age\u2009=\u200959\u2009years, interquartile range\u2009=\u200947\u201367, 156 [48%] female sex), of whom 137 (42%) had MG, 79 (24%) had CIDP, 43 (13%) had MMN, and 66 (20%) had IIM. PROM scores related to vaccination did not differ from scores unrelated to vaccination. In paired PROMs, MCID for deterioration was observed in three of 49 (6%) MG patients, of whom none reported a treatment change. In CIDP, MCID for deterioration was observed in eight of 29 patients (28%), of whom two of eight (25%) reported a treatment change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SARS\u2010CoV\u20102 vaccination had no effect on daily functioning in patients with autoimmune neuromuscular diseases, confirming its safety in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16409","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T16:41:21Z","timestamp":1725554481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Patient\u2010reported daily functioning after <scp>SARS<\/scp>\u2010<scp>CoV<\/scp>\u20102 vaccinations in autoimmune neuromuscular diseases"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2602-4364","authenticated-orcid":false,"given":"Koos P. J.","family":"van Dam","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurophysiology, Amsterdam Neuroscience, Amsterdam UMC, location AMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luuk","family":"Wieske","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurophysiology, Amsterdam Neuroscience, Amsterdam UMC, location AMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Department of Clinical Neurophysiology St. Antonius Hospital  Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen W.","family":"Stalman","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurophysiology, Amsterdam Neuroscience, Amsterdam UMC, location AMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Y. L.","family":"Kummer","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurophysiology, Amsterdam Neuroscience, Amsterdam UMC, location AMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Sanquin Research and Landsteiner Laboratory, Department of Immunopathology Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneke J.","family":"van der Kooi","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurophysiology, Amsterdam Neuroscience, Amsterdam UMC, location AMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Raaphorst","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurophysiology, Amsterdam Neuroscience, Amsterdam UMC, location AMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4571-044X","authenticated-orcid":false,"given":"Diederik","family":"van de Beek","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurophysiology, Amsterdam Neuroscience, Amsterdam UMC, location AMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4572-1501","authenticated-orcid":false,"given":"Jan J. 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M.","family":"Verschuuren","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabel M.","family":"Ruiter","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Brusse","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus MC University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter A.","family":"van Doorn","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus MC University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7842-0871","authenticated-orcid":false,"given":"Ad\u00e1ja E.","family":"Baars","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus MC University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Ludo","family":"van der Pol","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery Brain Center UMC Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Stephan","family":"Goedee","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery Brain Center UMC Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"ten Brinke","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery Brain Center UMC Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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