{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:52:39Z","timestamp":1780991559391,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T00:00:00Z","timestamp":1722643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Parent artery atherosclerosis is an important aetiology of recent subcortical ischaemic stroke (RSIS). However, comparisons of RSIS with different degrees of parent artery atherosclerosis are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospectively collected data from our multicentre cohort (all were tertiary centres) of the Stroke Imaging Package Study between 2015 and 2017 were retrospectively reviewed. The patients with RSIS defined as a single clinically relevant diffusion\u2010weighted imaging positive lesion in the territory of lenticulostriate arteries were categorized into three subgroups: (1) normal middle cerebral artery (MCA) on magnetic resonance angiography and high\u2010resolution magnetic resonance imaging (HR\u2010MRI); (2) low\u2010grade MCA atherosclerosis (normal or &lt;50% stenosis on magnetic resonance angiography and with MCA plaques on HR\u2010MRI); (3) steno\u2010occlusive MCA atherosclerosis (stenosis \u226550% or occlusion). The primary outcome was 90\u2010day functional dependence (modified Rankin Scale score &gt;2). The clinical and imaging findings were compared between subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 239 patients (median age 60.0 [52.0\u201367.0] years, 72% male) were enrolled, including 140 with normal MCA, 64 with low\u2010grade MCA atherosclerosis and 35 with steno\u2010occlusive MCA atherosclerosis. Patients with steno\u2010occlusive MCA atherosclerosis had the largest infarct volume. Low\u2010grade MCA atherosclerosis was independently associated with cerebral microbleeding, more severe perivascular spaces in basal ganglia and higher total cerebral small vessel disease burden. Low\u2010grade MCA atherosclerosis was an independent determinant of 90\u2010day functional dependence (odds ratio 3.897; 95% confidence interval 1.309\u201311.604).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggested RSIS with varying severity of parent artery atherosclerosis exhibits distinctive clinical and neuroimaging characteristics, with low\u2010grade MCA atherosclerosis associating with higher cerebral small vessel disease burden and worse prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16422","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T07:59:09Z","timestamp":1722671949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Small vessel disease burden and prognosis of recent subcortical ischaemic stroke differ by parent artery atherosclerosis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5724-3087","authenticated-orcid":false,"given":"Qian\u2010Qian","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"Department of Neurology, Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7486-1992","authenticated-orcid":false,"given":"Hui\u2010Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology General Hospital of Northern Theater Command  Shenyang 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