{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:53:40Z","timestamp":1790790820427,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Precise and timely diagnosis is crucial for the optimal use of emerging disease\u2010modifying treatments for Alzheimer disease (AD). Electroencephalography (EEG), which is noninvasive and cost\u2010effective, can capture neural abnormalities linked to various dementias. This study explores the use of individual alpha frequency (IAF) derived from EEG as a diagnostic and prognostic tool in cognitively impaired patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 375 patients from the tertiary Memory Clinic of IRCCS San Raffaele Hospital, Milan, Italy. Participants underwent clinical and neuropsychological assessments, brain imaging, cerebrospinal fluid biomarker analysis, and resting\u2010state EEG. Patients were categorized by amyloid status, the AT(N) classification system, clinical diagnosis, and mild cognitive impairment (MCI) progression to AD dementia. IAF was calculated and compared among study groups. Receiver operating characteristic (ROC) analysis was used to calculate its discriminative performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IAF was higher in amyloid\u2010negative subjects and varied significantly across AT(N) groups. ROC analysis confirmed IAF's ability to distinguish A\u2013T\u2013N\u2013 from the A+T+N+ and A+T\u2013N+ groups. IAF was lower in AD and Lewy body dementia patients compared to MCI and other dementia types, with moderate discriminatory capability. Among A+ MCI patients, IAF was significantly lower in those who converted to AD within 2\u2009years compared to stable MCI patients and predicted time to conversion (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>R<\/jats:italic>\u2009=\u20090.38).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IAF is a valuable tool for dementia diagnosis and prognosis, correlating with amyloid status and neurodegeneration. It effectively predicts MCI progression to AD, supporting its use in early, targeted interventions in the context of disease\u2010modifying treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16424","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T11:58:06Z","timestamp":1722513486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Analysis of individual alpha frequency in a large cohort from a tertiary memory center"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6544-410X","authenticated-orcid":false,"given":"Giordano","family":"Cecchetti","sequence":"first","affiliation":[{"name":"Neurology Unit IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Neurophysiology Service IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Neuroimaging Research Unit, Division of Neuroscience IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3121-4979","authenticated-orcid":false,"given":"Federica","family":"Agosta","sequence":"additional","affiliation":[{"name":"Neurology Unit IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Neuroimaging Research Unit, Division of Neuroscience IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5804-3378","authenticated-orcid":false,"given":"Elisa","family":"Canu","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit, Division of Neuroscience IRCCS San Raffaele Scientific Institute  Milan 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