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This study aimed to determine the impact of neurological and imaging features in relation to the time of CAA diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with probable CAA according to the Boston criteria version 1.5, treated between 2010 and 2020 in our neurocentre, were identified through a keyword search in our medical database. Neuroimaging was assessed using Boston criteria versions 1.5 and 2.0. Medical records with primary focus on the clinical course and the occurrence of transient focal neurological episodes were prospectively evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010eight out of 81 patients (46.9%) exhibited transient focal neurological episodes, most often sensory (13.2%) or aphasic disorders (13.2%), or permanent deficits at a mean time interval of 31.1\u2009months (SD \u00b126.3; range 1\u2013108\u2009months) before diagnosis of probable CAA (Boston criteria version 1.5). If using Boston criteria version 2.0, all patients receiving magnetic resonance imaging (MRI) met the criteria for probable CAA, and diagnosis could have been made on average 44\u2009months earlier. Four patients were younger than 50\u2009years, three of them with supporting pathology. Cognitive deficits were most common (34.6%) at the time of diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010haemorrhagic MRI markers enhance the sensitivity of diagnosing probable CAA; however, further prospective studies are proposed to establish a minimum age for inclusion. As the neurological overture of CAA may occur several years before clinical diagnosis, early clarification by MRI including haemosensitive sequences are suggested.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16425","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T10:20:52Z","timestamp":1722939652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical and neuroimaging precursors in cerebral amyloid angiopathy: impact of the Boston criteria version 2.0"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6437-6793","authenticated-orcid":false,"given":"Stefan","family":"Weidauer","sequence":"first","affiliation":[{"name":"Institute of Neuroradiology, University Hospital Goethe University Frankfurt  Frankfurt am Main 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