{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:19:52Z","timestamp":1787498392380,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["114025101"],"award-info":[{"award-number":["114025101"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neurobehavioural comorbidities have a detrimental effect on the quality of life of people with epilepsy, yet tracking their impact is challenging as behaviour may vary with seizures and anti\u2010seizure medication (ASM) side effects. Smartphones have the potential to monitor day\u2010to\u2010day neurobehavioural patterns objectively. We present the case of a man in his late twenties with drug\u2010resistant focal epilepsy in whom we ascertained the effects of ASM withdrawal and a convulsive seizure on his touchscreen interactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using a dedicated app, we recorded over 185\u2009days the timestamps of 718,357 interactions. We divided the various smartphone behaviours according to the next\u2010interval dynamics of the interactions by using a joint interval distribution (JID). During two ASM load transitions, namely before versus during tapering and tapering versus restarting medication, we used cluster\u2010based permutation tests to compare the JIDs. We also compared the JID of the seizure day to the average of the previous 3\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cluster\u2010based permutation tests revealed significant differences, with accelerated next\u2010interval dynamics during tapering and a reversal upon medication restart. The day of the convulsion exhibited a marked slowing of next\u2010interval dynamics compared to the preceding 3\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that the temporal dynamics of smartphone touchscreen interactions may help monitor neurobehavioural comorbidities in neurological care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.16433","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T08:44:18Z","timestamp":1723020258000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Real\u2010world smartphone data can trace the behavioural impact of epilepsy: A case study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8375-5975","authenticated-orcid":false,"given":"Arthur R.","family":"van Nieuw Amerongen","sequence":"first","affiliation":[{"name":"Stichting Epilepsie Instellingen Nederland (SEIN)  Heemstede The Netherlands"},{"name":"Department of Neurology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marthe","family":"Meppelink","sequence":"additional","affiliation":[{"name":"Stichting Epilepsie Instellingen Nederland (SEIN)  Heemstede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2924-5146","authenticated-orcid":false,"given":"Arko","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Cognitive Psychology Unit, Institute of Psychology Leiden University  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1435-8970","authenticated-orcid":false,"given":"Roland 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