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Sumatriptan\u2010naproxen sodium, a single, fixed\u2010dose combination tablet comprising sumatriptan 85\u2009mg and naproxen sodium 500\u2009mg, was developed with the rationale of targeting multiple putative mechanisms involved in the pathogenesis of migraine to optimise acute migraine care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A narrative review of clinical trials investigating sumatriptan\u2010naproxen sodium for both adults and adolescents was performed in March 2024.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Across a total of 14 clinical trials in nine publications, sumatriptan\u2010naproxen sodium offered greater efficacy for 2\u2010h pain freedom (14\/14) and sustained pain\u2010free response up to 24\u2009h (13\/14) compared with monotherapy and\/or placebo for both adult and adolescent study participants with an acceptable and well\u2010tolerated adverse effect profile. Clinical trial data also demonstrates the effectiveness of sumatriptan\u2010naproxen sodium in participants with allodynia, probable migraine, menstrual\u2010related migraine and those with poor responses to acute, non\u2010specific, migraine medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Multi\u2010mechanistic therapeutic agents offer an opportunity to optimise acute medications by targeting multiple mediators involved in the pathogenesis of migraine. Sumatriptan\u2010naproxen sodium resulted in greater initial and sustained pain freedom, compared with either sumatriptan, naproxen\u2010sodium and\/or placebo, for the treatment of single or multiple attacks of migraine across both adult and adolescent study populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16434","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T14:40:16Z","timestamp":1727275216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sumatriptan\u2010naproxen sodium in migraine: A review"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3330-0451","authenticated-orcid":false,"given":"Robyn\u2010Jenia","family":"Wilcha","sequence":"first","affiliation":[{"name":"Headache Group, NIHR King's Clinical Research Facility and SLaM Biomedical Research Centre, The Wolfson Sensory, Pain and Regeneration Research Centre, Institute of Psychiatry, Psychology and Neuroscience King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazia K.","family":"Afridi","sequence":"additional","affiliation":[{"name":"Neurology Department Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5670-3755","authenticated-orcid":false,"given":"Piero","family":"Barbanti","sequence":"additional","affiliation":[{"name":"Headache and Pain Unit IRCCS San Raffaele Roma  Rome Italy"},{"name":"San Raffaele University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6556-8612","authenticated-orcid":false,"given":"Hans Christoph","family":"Diener","sequence":"additional","affiliation":[{"name":"Department of Neuroepidemiology, Institute for Medical Informatics, Biometry and Epidemiology (IMIBE) Medical Faculty of the University Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim Patrick","family":"J\u00fcrgens","sequence":"additional","affiliation":[{"name":"Neurologisches Zentrum Neurologische Klinik, KMG Klinikum G\u00fcstrow  G\u00fcstrow Germany"},{"name":"Klinik und Poliklinik f\u00fcr Neurologie Kopfschmerzzentrum Nord\u2010Ost  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Lanteri\u2010Minet","sequence":"additional","affiliation":[{"name":"Pain D\u00e9partment CHU Nice and FHU InovPain Universit\u00e9 C\u00f4te Azur  Nice France"},{"name":"Inserm U1107, Neuro\u2010Dol, Trigeminal Pain and Migraine Universit\u00e9 Clermont Auvergne  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lucas","sequence":"additional","affiliation":[{"name":"Pain Clinic, Service de Neurochirurgie, H\u00f4pital Salengro CHU de Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jer\u00f4me","family":"Mawet","sequence":"additional","affiliation":[{"name":"Emergency Headache Centre, Department of Neurology (J.M.) 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