{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:23:08Z","timestamp":1792002188803,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["Grant No: 306377\/2022\u20105"],"award-info":[{"award-number":["Grant No: 306377\/2022\u20105"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cognitive decline is prevalent in maintenance hemodialysis patients. The blood\u2013brain barrier has been implicated in cognitive decline. In this prospective cohort study, we investigated the associations between endothelium\u2010related biomarkers and steeper cognitive decline in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cognitive function was assessed using the Portuguese\u2010adapted Cambridge Cognitive Examination (CAMCOG) with items of the Mini\u2010Mental State Examination (MMSE). Endothelium\u2010related biomarkers included syndecan\u20101, ICAM\u20101, VCAM\u20101 and angiopoietin\u20102 (AGPT2). Patients were followed up for 4\u2009years, and cognitive assessments were repeated. Multinomial regression analyses were performed to evaluate associations between biomarkers and cognitive decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 216 patients completed the test battery at baseline. After 4\u2009years, 102 patients had follow\u2010up data. There was a significant decrease in cognitive function according to the CAMCOG and MMSE scores: a change of \u22120.39 (95% CI \u22120.27 to \u22120.51) and \u22120.51 (95% CI \u22120.27 to \u22120.76) standard deviation (SD) of the baseline scores. Additionally, executive function but not memory significantly decreased. Syndecan\u20101 level was independently associated with steeper cognitive decline; each increase in the SD of the syndecan\u20101 level was associated with a decrease in the CAMCOG of 0.20 (95% CI 0.07\u20130.33) SD from baseline. Syndecan\u20101 was associated with a steeper decline in MMSE score (<jats:italic>\u03b2<\/jats:italic> 0.54, 95% CI 0.28\u20130.81) and executive function (<jats:italic>\u03b2<\/jats:italic> 0.17, 95% CI 0.02\u20130.32). Syndecan\u20101 predicted severe cognitive impairment with an area under the curve for receiver operating characteristic curves of 0.75 (95% CI 0.64\u20130.83).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings highlight the potential of syndecan\u20101, a biomarker of endothelium glycocalyx derangement, as a predictor of steeper cognitive decline in prevalent hemodialysis patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16438","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T04:59:20Z","timestamp":1723525160000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Endothelium\u2010related biomarkers and cognitive decline in prevalent hemodialysis patients: A prospective cohort study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0409-6113","authenticated-orcid":false,"given":"Alexandre Braga","family":"Lib\u00f3rio","sequence":"first","affiliation":[{"name":"Medical Sciences Postgraduate Program Universidade de Fortaleza\u2010UNIFOR  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Maroni Marques Freire","family":"de Medeiros","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical School Federal University of Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia Lib\u00f3rio","family":"Santos","sequence":"additional","affiliation":[{"name":"Medical Program Universidade de Fortaleza\u2010UNIFOR  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Silveira","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Medical Program Universidade de Fortaleza\u2010UNIFOR  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gdayllon 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