{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:01:50Z","timestamp":1793073710241,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>The diagnostic criteria for myelin oligodendrocyte glycoprotein antibody (MOG\u2010IgG)\u2010associated disease (MOGAD) were published in 2023. We aimed to determine the performance of the new criteria in Latin American (LATAM) patients compared with the 2018 criteria and explore the significance of MOG\u2013IgG titers in diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed the medical records of LATAM (Argentina, Chile, Brazil, Peru, Ecuador, and Colombia) adult patients with one clinical MOGAD event and MOG\u2010IgG positivity confirmed by cell\u2010based assay. Both 2018 and 2023 MOGAD criteria were applied, calculating diagnostic performance indicators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 171 patients (predominantly females, mean age at first attack\u2009=\u200934.1\u2009years, mean disease duration\u2009=\u20094.5\u2009years), 98.2% patients met the 2018 criteria, and of those who did not fulfill diagnostic criteria (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093), all tested positive for MOG\u2010IgG (one low\u2010positive and two without reported titer). Additionally, 144 (84.2%) patients met the 2023 criteria, of whom 57 (39.5%) had MOG\u2010IgG+ titer information (19 clearly positive and 38 low\u2010positive), whereas 87 (60.5%) patients had no MOG\u2010IgG titer. All 144 patients met diagnostic supporting criteria. The remaining 27 patients did not meet the 2023 MOGAD criteria due to low MOG\u2010IgG (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912) or lack of titer antibody access (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915), associated with the absence of supporting criteria. The 2023 MOGAD criteria showed a sensitivity of 86% (95% confidence interval\u2009=\u20090.80\u20130.91) and specificity of 100% compared to the 2018 criteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings support the diagnostic utility of the 2023 MOGAD criteria in an LATAM cohort in real\u2010world practice, despite limited access to MOG\u2010IgG titration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.16445","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T14:40:25Z","timestamp":1726584025000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The real\u2010world applicability of the 2023 international myelin oligodendrocyte glycoprotein antibody\u2010associated disease criteria in a Latin American cohort"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7435-5726","authenticated-orcid":false,"given":"Edgar","family":"Carnero Contentti","sequence":"first","affiliation":[{"name":"Neuroimmunology Unit, Department of Neurosciences Hospital Aleman  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Pestchanker","sequence":"additional","affiliation":[{"name":"Neurology Department Dr. Ram\u00f3n Carrillo Central Hospital  San Luis Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7330-5433","authenticated-orcid":false,"given":"Ethel","family":"Ciampi","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Dr. S\u00f3tero del R\u00edo y Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Castro Suarez","sequence":"additional","affiliation":[{"name":"Basic Research Center in Dementia and Central Nervous System Demyelinating Diseases Instituto Nacional de Ciencias Neurol\u00f3gicas  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6896-3052","authenticated-orcid":false,"given":"Cesar","family":"Caparo Zamalloa","sequence":"additional","affiliation":[{"name":"Basic Research Center in Dementia and Central Nervous System Demyelinating Diseases Instituto Nacional de Ciencias Neurol\u00f3gicas  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanesa","family":"Daccach Marques","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Messias","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ignacio","family":"Gortari","sequence":"additional","affiliation":[{"name":"Neurology private practice  Pereira Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Tkachuk","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital de Cl\u00ednicas  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5866-2419","authenticated-orcid":false,"given":"Berenice","family":"Silva","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Mainella","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Espa\u00f1ol de Rosario  Santa Fe Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa\u00fal","family":"Reyes","sequence":"additional","affiliation":[{"name":"Neurology Department Fundaci\u00f3n Santa Fe de Bogot\u00e1  Bogot\u00e1 Colombia"},{"name":"School of Medicine Universidad de los Andes  Bogot\u00e1 Colombia"},{"name":"Blizard Institute, Barts and the London School of Medicine and Dentistry Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Toro","sequence":"additional","affiliation":[{"name":"Neurology Department Fundaci\u00f3n Santa Fe de Bogot\u00e1  Bogot\u00e1 Colombia"},{"name":"School of Medicine Universidad de los Andes  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Neurology Department Fundaci\u00f3n Santa Fe de Bogot\u00e1  Bogot\u00e1 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