{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T09:53:12Z","timestamp":1794217992850,"version":"4.8.0"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["OF\u2010LCG000207"],"award-info":[{"award-number":["OF\u2010LCG000207"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>This study was undertaken to conduct a meta\u2010analysis on the prevalence of aspiration pneumonia (AP) and hospital mortality in Parkinson disease (PD) as well as the risk of AP in PD patients compared to controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched MEDLINE and Embase from inception to 19 March 2024 to identify cross\u2010sectional, cohort, and case\u2013control studies comparing the frequency of AP and hospital mortality in PD patients. We computed risk ratios (RRs) with accompanying 95% confidence intervals (CIs) for each study and pooled the results using a random\u2010effects meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 781 studies were initially screened, and 13 studies involving 541,785,587 patients were included. Patients with PD had &gt;3 times higher risk of AP compared to controls (RR\u2009=\u20093.30, 95% CI\u2009=\u20091.82\u20136.00,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). This increased risk was similar in both cohort studies (RR\u2009=\u20093.01, 95% CI\u2009=\u20091.10\u20138.24,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and case\u2013control studies (RR\u2009=\u20093.86, 95% CI\u2009=\u20093.84\u20133.87,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001). The prevalence of AP in 12 studies was 2.74% (95% CI\u2009=\u20091.69\u20134.41), and hospital mortality was 10% in six studies (10.0%, 95% CI\u2009=\u20095.32\u201318.0). Prevalence of AP was higher in studies with smaller sample size (5.26%, 95% CI\u2009=\u20093.08\u20138.83 vs. 2.06%, 95% CI\u2009=\u20091.19\u20133.55,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our meta\u2010analysis showed that patients with PD had &gt;3 times higher risk of AP, with an average 2.74% prevalence and 10.0% hospital mortality. Early recognition and treatment of AP in PD patients will help reduce morbidity and mortality. A multidisciplinary holistic approach is needed to address the multifactorial causes of AP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.16449","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T16:39:07Z","timestamp":1725554347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Risk of aspiration pneumonia and hospital mortality in Parkinson disease: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8580-4141","authenticated-orcid":false,"given":"Wei Yu","family":"Chua","sequence":"first","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Dong James","family":"Wang","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0265-2809","authenticated-orcid":false,"given":"Claire Kar Min","family":"Chan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010Ling","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Singapore General Hospital Campus  Singapore"},{"name":"Neuroscience and Behavioral Disorders Duke\u2010NUS Medical School  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eng\u2010King","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Singapore General Hospital Campus  Singapore"},{"name":"Neuroscience and Behavioral Disorders Duke\u2010NUS Medical School  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