{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:35:35Z","timestamp":1790796935983,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Although there is extensive evidence about the safety of monoclonal antibodies against calcitonin gene\u2010related peptide (anti\u2010CGRP mAbs) in combination with traditional drugs, scarce data are available on the safety of their combination with other mAbs. This study aimed to evaluate the 6\u2010month effectiveness and tolerability of anti\u2010CGRP mAbs in combination with other mAbs for different diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients included in the Italian Headache Registry and treated concomitantly with an anti\u2010CGRP mAb and another mAb were included. Effectiveness outcomes for migraine included reduction from baseline of monthly headache days (MHDs), Migraine Disability Assessment (MIDAS) score, Headache Impact Test\u20106 (HIT\u20106) scores, and Patients' Global Impression of Change (PGIC) scale. Adverse events (AEs) were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010eight patients were included. In 27 patients (71.1%), the anti\u2010CGRP mAb was added to a previously ongoing mAb. Nine patients (23.7%) discontinued one of the two mAbs before the end of treatment (seven discontinued the anti\u2010CGRP mAb and two the other mAb). One patient discontinued for AEs. Anti\u2010CGRP mAbs were discontinued due to ineffectiveness (<jats:italic>n<\/jats:italic>\u2009=\u20095, 55.5%) and one each (11.1%) for clinical remission and lost to follow\u2010up. MHDs significantly decreased from baseline to 3\u2009months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and 6\u2009months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), as did the MIDAS and the HIT\u20106 scores at 3 and 6\u2009months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). For anti\u2010CGRP mAbs, 27.4% of patients reported PGIC \u2265\u20095 at 3\u2009months and 48.3% at 6\u2009months. Mild AEs associated with introduction of a second mAb were detected in six patients (15.8%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this real\u2010world study, anti\u2010CGRP mAbs showed safety and effectiveness when administered concomitantly with other mAbs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16450","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T13:40:18Z","timestamp":1726580418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association of anti\u2010calcitonin gene\u2010related peptide with other monoclonal antibodies for different diseases: A multicenter, prospective, cohort study"],"prefix":"10.1111","volume":"31","author":[{"given":"Luigi Francesco","family":"Iannone","sequence":"first","affiliation":[{"name":"Section of Clinical Pharmacology and Oncology, Department of Health Sciences University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6016-3141","authenticated-orcid":false,"given":"Marina","family":"Romozzi","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0601-0475","authenticated-orcid":false,"given":"Antonio","family":"Russo","sequence":"additional","affiliation":[{"name":"Headache Center, Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Saporito","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences University of L'Aquila  L'Aquila Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"De Santis","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences University of L'Aquila  L'Aquila Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Ornello","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences University of L'Aquila  L'Aquila Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Sances","sequence":"additional","affiliation":[{"name":"Headache Science and Neurorehabilitation Unit IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Vaghi","sequence":"additional","affiliation":[{"name":"Headache Science and Neurorehabilitation Unit IRCCS Mondino Foundation  Pavia Italy"},{"name":"Department of Brain and Behavioral Sciences University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1513-2113","authenticated-orcid":false,"given":"Cristina","family":"Tassorelli","sequence":"additional","affiliation":[{"name":"Headache Science and Neurorehabilitation Unit IRCCS Mondino Foundation  Pavia Italy"},{"name":"Department of Brain and Behavioral Sciences University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5113-2017","authenticated-orcid":false,"given":"Maria","family":"Albanese","sequence":"additional","affiliation":[{"name":"Regional Referral Headache Center, Neurology Unit Tor Vergata University Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Guerzoni","sequence":"additional","affiliation":[{"name":"Digital and Predictive Medicine, Pharmacology, and Clinical Metabolic Toxicology, Headache Center and Drug Abuse Laboratory of Clinical Pharmacology and Pharmacogenomics, Department of Specialist Medicines AOU Policlinico di Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonsina","family":"Casalena","sequence":"additional","affiliation":[{"name":"Neurology Unit \u201cG. 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