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Exacerbation frequency, adverse events (AEs) related to immunosuppressant therapy and healthcare resource utilization (HCRU) are not well understood. Our study aimed to describe long\u2010term clinical outcomes, drug\u2010related AEs and estimated HCRU in gMG patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort analysis of clinical data from patients with gMG followed\u2010up over eight consecutive years in a Spanish referral unit. Myasthenia Gravis Foundation of America (MGFA) clinical classification, MGFA post\u2010interventional status (MGFA\u2010PIS), Myasthenia Gravis Activities of Daily Living (MG\u2010ADL) score, exacerbations, MG crises, therapies, AEs reported, specialist consultations and emergency room visits were studied biannually. An estimation of HRCU was made based on these data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Some 220 patients newly diagnosed with gMG were included. Ninety percent were seropositive (84.5% anti\u2010acetylcholine receptor [AChR], 5.9% anti\u2010muscle\u2010specific kinase [MuSK]). Baseline mean MG\u2010ADL score was 5.04 points (SD 3.17), improving to 0.7 points (SD 1.40) after 8\u2009years. Exacerbations were more frequent in years 1\u20132 (30.1%) but still occurred in years 7\u20138 (20.2%). Myasthenic crisis frequency remained 1% in years 7\u20138. Eighty\u2010nine percent achieved MGFA\u2010PIS minimal manifestations or better at 8\u2009years. Fifty\u2010one percent of patients reported at least one AE during the study period, leading to drug withdrawal in approximately 20% of cases. HCRU decreased between years 1\u20132 to years 7\u20138 with an estimated cost of MG from 8074.19 \u20ac per patient\/year to 1679.46 \u20ac, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a group of MG patients that suffers from persistent symptoms and exacerbations (11%\u201320%) or MG crises, and drug AEs, which may increase disease burden and impact on the healthcare system.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16463","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T10:40:49Z","timestamp":1733222449000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Persistent symptoms, exacerbations and drug side effects despite treatment in myasthenia 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