{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:13:53Z","timestamp":1781104433946,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003197","name":"Agenzia Italiana del Farmaco, Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The purpose was to describe the use patterns of pharmacological and non\u2010pharmacological therapies and investigate potential determinants of riluzole use in patients newly diagnosed with amyotrophic lateral sclerosis (ALS) in three Italian regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Amyotrophic lateral sclerosis patients were selected from administrative healthcare databases of Latium, Tuscany and Umbria from 1 January 2014 to 31 December 2019 based on hospital\u2010 and disease\u2010specific co\u2010payment exemption data. The first trace of ALS was considered the index date. Incident ALS cases were those without a trace of ALS during the 3\u2010year look back. Patients were described in terms of demographics, clinical characteristics and drug use at baseline, and were classified into four categories based on riluzole use in the 2\u2009years before and 1\u2009year after the index date: prevalent, incident, former users and non\u2010users. Use of symptomatic pharmacological and non\u2010pharmacological therapies was described across these categories during 12\u2009months after the index date. Determinants of riluzole use were also investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and conclusions<\/jats:title><jats:p>A total of 1636 ALS incident subjects were detected in the three regions, mainly aged 65\u201374\u2009years. Patients were generally fragile with a high prevalence of comorbidities at baseline. Riluzole was used by 27.4% of the overall study cohort at baseline and steeply increased in the first year after the index date differently between regions (Latium 61.2%, Tuscany 85.0%, Umbria 76.5%), with about half of the subjects being incident users. In the 12\u2009months after the index date, also symptomatic therapies increased, in riluzole users and non\u2010users. Determinants analysis showed that higher patient severity and complexity were associated with a lower likelihood of being treated with riluzole.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16470","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T09:04:52Z","timestamp":1726736692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacological and non\u2010pharmacological treatments in amyotrophic lateral sclerosis: an Italian real\u2010world data study"],"prefix":"10.1111","volume":"31","author":[{"given":"Olga","family":"Paoletti","sequence":"first","affiliation":[{"name":"Pharmacoepidemiology Unit Regional Health Agency of Tuscany  Florence 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