{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:32Z","timestamp":1787014172340,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,22]],"date-time":"2024-09-22T00:00:00Z","timestamp":1726963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2016T086"],"award-info":[{"award-number":["2016T086"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Data on health\u2010related quality of life (HRQoL) and mood in cerebral amyloid angiopathy (CAA), a disease characterized by stroke and cognitive decline, are limited. We aimed to investigate the impacted domains of life, value\u2010based HRQoL and the prevalence of depression and anxiety in patients with CAA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross\u2010sectional study of patients with sporadic (s)CAA, lobar dominant mixed CAA and hypertensive arteriopathy (mixed CAA\u2010HTA), or Dutch\u2010type hereditary (D\u2010)CAA, from prospective outpatient clinic cohorts. Participants completed four questionnaires: the EuroQoL 5 dimensions 5\u2010level questionnaire (EQ\u20105D\u20105L; EQ\u2010VAS for visual analogue scale; EQ\u2010Index for index rating), the Short\u2010Form 36 questionnaire (SF\u201036), the Center for Epidemiologic Studies\u2014Depression scale (CES\u2010D), and the Hospital Anxiety and Depression Scale (HADS; \u2010D for depression and \u2010A for anxiety subscales). The EQ\u20105D\u20105L assesses the domains mobility, self\u2010care, usual activities, pain\/discomfort and anxiety\/depression. The SF\u201036 domains are physical functioning, social functioning, physical role limitations, emotional role limitations, mental health, vitality, bodily pain, and general health perceptions. We compared age\u2010 and sex\u2010 adjusted HRQoL (SF\u201036 domain scores; EQ\u2010VAS; EQ\u2010Index) to the Dutch normative population, and estimated the prevalences of current depression (either: history of depression or current use of antidepressants, with high score on CES\u2010D [\u226516] and\/or HADS\u2010D [\u22658]; or high score on both depression questionnaires) and anxiety (HADS\u2010A\u2009\u2265\u20098).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 179 patients: 77 with sCAA (mean age: 72\u2009years, women: 36%), 31 with mixed CAA\u2010HTA (68\u2009years, women: 29%), and 71 with D\u2010CAA (56\u2009years, women: 52%, symptomatic: 35 [49%]). The SF\u201036 profiles of all patient groups were similar, negatively differing from the norm in emotional role functioning, social functioning and vitality. The EQ\u2010VAS score of patients (mean [SD] sCAA: 76 [16], D\u2010CAA: 77 [15]) was similar to the norm, as was the EQ\u2010Index score. Fifteen patients with sCAA (23%; 95% confidence interval [CI] 13%\u201333%), seven with mixed CAA\u2010HTA (27%; 95% CI 10%\u201344%) and eight with D\u2010CAA (14%; 95% CI 5%\u201322%) were noted as having depression. The prevalences of anxiety and depression were equivalent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found that CAA influenced emotional role functioning and aspects linked to social engagement consistently across its subtypes. One quarter of patients exhibited depressive or anxiety symptoms. Recognizing these impacted domains could enhance overall well\u2010being.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.16476","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T01:44:32Z","timestamp":1731375872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Quality of life, depression and anxiety in cerebral amyloid angiopathy: A cross\u2010sectional study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1429-6853","authenticated-orcid":false,"given":"Kanishk","family":"Kaushik","sequence":"first","affiliation":[{"name":"Department of Neurology Leiden University Medical Center (LUMC)  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha G.","family":"Waslam","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Center (LUMC)  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinier G. 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