{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:07:48Z","timestamp":1784038068597,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Pure autonomic failure (PAF) presents primarily as cardiovascular autonomic failure and may phenoconvert to other neurodegenerative disorders. However, the involvement of other autonomic functions has been poorly evaluated. This study aims to characterize genitourinary and bowel dysfunction and explore their relationship with cardiovascular autonomic dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pure autonomic failure patients underwent cardiovascular autonomic testing and an assessment of pelvic autonomic dysfunction using urinary, sexual symptoms questionnaires and a bladder diary. Demographic, clinical features and related medical comorbidities were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five patients (10 males) with PAF were included (mean age 71\u2009\u00b1\u20098\u2009years; disease duration 13\u2009\u00b1\u20098\u2009years). 96% (24\/25) reported lower urinary tract symptoms, of which overactive bladder symptoms were most commonly reported (<jats:italic>n<\/jats:italic>\u2009=\u200923; 92%; median overactive subscore 8, interquartile range [IQR] 3\u201311), followed by voiding difficulties (<jats:italic>n<\/jats:italic>\u2009=\u200919; 76%; median low stream subscore 2, IQR 1\u20133) using the Urinary Symptom Profile; however, only four (16%) required clean intermittent self\u2010catheterization. Sexual dysfunction was common (<jats:italic>n<\/jats:italic>\u2009=\u200921; 84%) using the Arizona Sexual Experience Scale. Mild faecal incontinence and constipation were reported. 86% (19\/22) had nocturnal polyuria (NP) and the median NP index was 47% (IQR 38%\u201351%; normal range &lt;33%). 77% (10\/13) had voiding dysfunction and 31% (4\/13) had post\u2010void residual urine &gt;100\u2009mL. There were no significant correlations between the need for catheterization and the degree of NP with age, disease duration and cardiovascular autonomic parameters (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nocturnal polyuria, genitourinary and bowel symptoms are commonly seen in PAF. The pathophysiology of NP in PAF is most likely multifactorial and may occur independent of cardiovascular autonomic failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16486","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T05:34:11Z","timestamp":1727674451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pelvic autonomic dysfunction is common in patients with pure autonomic failure"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6183-0997","authenticated-orcid":false,"given":"E.","family":"Vichayanrat","sequence":"first","affiliation":[{"name":"Department of Uro\u2010Neurology National Hospital for Neurology and Neurosurgery  London UK"},{"name":"Autonomic Unit National Hospital for Neurology and Neurosurgery  London UK"},{"name":"UCL Queen Square Institute of Neurology, Faculty of Brain Sciences University College London  London 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