{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T22:00:53Z","timestamp":1772143253395,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Decompressive hemicraniectomy (DH) improves survival and functional outcome in large middle cerebral artery (MCA) infarcts. However, long\u2010term cognitive outcomes after DH remain underexplored. In a cohort of patients with large right\u2010hemisphere MCA infarction undergoing DH, we assessed the rates of long\u2010term cognitive impairment over 3\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively evaluated consecutive patients included in the Lille Decompressive Surgery Database (May 2005\u2013April 2022) undergoing DH according to existing guidelines for large hemisphere MCA infarction. We included patients with right\u2010sided stroke and\u00a0screened with the Mini\u2010Mental State Examination (MMSE) in at least one of the prespecified follow\u2010ups (3\u2010month, 1\u2010year, 3\u2010year). Cognitive impairment was defined as an MMSE score &lt;\u200924. We included only right\u2010hemisphere strokes to avoid testing biases related to severe aphasia. We compared clinical and neuroimaging data in patients with and without cognitive impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred four patients underwent DH during the study period. Among 3\u2010month survivors, 95 had a right\u2010hemisphere stroke and underwent at least one cognitive screening (median age\u2009=\u200951\u2009years, 56.8% men). Forty\u2010four patients (46.3%) exhibited cognitive impairment at least once during the 3\u2010year follow\u2010up. Baseline characteristics did not significantly differ between patients with and without cognitive impairment. Regarding long\u2010term temporal trends, cognitive impairment was observed in 23 of 76 (30.3%), 25 of 80 (31.3%), and 19 of 66 (28.8%) patients at 3\u2010month, 1\u2010year, and 3\u2010year follow\u2010up, respectively, and it was associated with higher rates of functional disability (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The persistently high rates of cognitive impairment after DH highlight the importance of cognitive monitoring to improve the long\u2010term management of survivors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16492","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T05:40:11Z","timestamp":1730353211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010term cognitive outcomes after decompressive hemicraniectomy for right\u2010hemisphere large middle cerebral artery ischemic stroke"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2313-2124","authenticated-orcid":false,"given":"Giuseppe","family":"Scopelliti","sequence":"first","affiliation":[{"name":"Universit\u00e9 Lille, Inserm, CHU Lille, U1172 \u2010 LilNCog \u2010 Lille Neuroscience &amp; Cognition  Lille France"},{"name":"Neurology Unit Luigi Sacco University Hospital  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilde","family":"Henon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lille, Inserm, CHU Lille, U1172 \u2010 LilNCog \u2010 Lille Neuroscience &amp; Cognition  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Masheka\u2010Cishesa","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lille, Inserm, CHU Lille, U1172 \u2010 LilNCog \u2010 Lille Neuroscience &amp; Cognition  Lille France"},{"name":"Department of Neurology CH Dunkirk  Dunkirk France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Labreuche","sequence":"additional","affiliation":[{"name":"Department of Biostatistics CHU Lille  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Kuchcinski","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Universit\u00e9 Lille, Inserm, CHU Lille, U1172 \u2010 LilNCog \u2010 Lille Neuroscience &amp; Cognition  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabih","family":"Aboukais","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Univ. Lille, Inserm U1189, CHU Lille  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Cordonnier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lille, Inserm, CHU Lille, U1172 \u2010 LilNCog \u2010 Lille Neuroscience &amp; Cognition  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4199-995X","authenticated-orcid":false,"given":"Barbara","family":"Casolla","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Cote d'Azur UR2CA\u2010URRIS, Unit\u00e9 Neurovasculaire, CHU H\u00f4pital Pasteur 2  Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.032359"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003200\/-\/DC1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/23969873211014112"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000211"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/JNNP-2019-322280"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMANEUROL.2020.3745"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001882"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.032215"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-11-77"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70047-X"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00415-012-6810-1\/METRICS"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311367"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337454"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.5.604"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.8.1304"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.646570"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010049"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70036-4"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.485649"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011145.PUB2"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JPSYCHIRES.2008.04.014"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00415-009-5387-9"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(23)00257-X"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0033-2909.112.1.155"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98853-5"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2014.05.010"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00415-012-6819-5\/METRICS"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30442-3"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/BRAINSCI14010077"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63600-3.00016-7"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.REHAB.2014.12.001"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930231205787"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.16492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T05:17:32Z","timestamp":1737955052000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.16492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,30]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/ene.16492"],"URL":"https:\/\/doi.org\/10.1111\/ene.16492","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,30]]},"assertion":[{"value":"2024-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16492"}}