{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T13:46:27Z","timestamp":1776001587091,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["328615"],"award-info":[{"award-number":["328615"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Several studies have reported substantial comorbidity between epilepsy and migraine. Most of these were based on clinical cohorts or used unvalidated diagnostic instruments. Our study re\u2010examined this association in a large general population cohort using validated diagnoses for both disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 65,407 participants (\u226520\u2009years old) from HUNT (the Tr\u00f8ndelag Health Study) were classified for migraine and nonmigraine headache using a validated questionnaire. Medical record review was used to validate and classify epilepsy in 364 participants (cases), who were compared with 63,298 participants without epilepsy (controls). The association between epilepsy and migraine was analysed using logistic regression adjusted for sex and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with epilepsy had no increased prevalence of migraine (odds ratio [OR] =\u20090.95, 95% confidence interval [CI] =\u20090.68\u20131.33) or nonmigraine headache (OR\u2009=\u20091.18, 95% CI\u2009=\u20090.93\u20131.50) compared to controls. When stratified by headache frequency, epilepsy was associated with a higher prevalence of migraine with highly frequent headache (\u22657\u2009days\/month; OR\u2009=\u20091.73, 95% CI\u2009=\u20091.08\u20132.78).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Migraine was equally common in people with and without epilepsy. Patients with epilepsy who suffered from migraine were more prone to having highly frequent migraine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16496","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T11:28:11Z","timestamp":1727436491000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Relationship between migraine and epilepsy in a large population\u2010based cohort: The HUNT Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5089-1695","authenticated-orcid":false,"given":"Helene","family":"Engstrand","sequence":"first","affiliation":[{"name":"Department of Research and Innovation, Division of Clinical Neuroscience Oslo University Hospital  Oslo Norway"},{"name":"Department of Neuromedicine and Movement, Norwegian Centre for Headache Research (NorHead) Norwegian University of Science and Technology  Trondheim Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine University of Oslo  Oslo Norway"},{"name":"Department of Neurology Oslo University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eline","family":"Revdal","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Neurophysiology St. Olav's University Hospital  Trondheim Norway"},{"name":"Department of Neuromedicine and Movement Science Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Bengtson","family":"Argren","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine and Movement, Norwegian Centre for Headache Research (NorHead) Norwegian University of Science and Technology  Trondheim Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine University of Oslo  Oslo Norway"},{"name":"Department of Neurology Oslo University Hospital  Oslo 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