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The concept of \u201cbody\u2010first\u201d and \u201cbrain\u2010first\u201d subtypes in PD has been proposed, but the correlation of PD subtype with LUTS remains unclear. We aimed to investigate the disparities in urological dysfunctions between body\u2010first and brain\u2010first subtypes of PD using urodynamic studies (UDS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed patients with PD (disease duration &lt;3\u2009years) who had undergone UDS and completed urological questionnaires (Overactive Bladder Symptom Score [OABSS] and International Prostate Symptom Score [IPSS]) and a voiding diary. Patients were categorized as having body\u2010first or brain\u2010first PD based on cardiac sympathetic denervation (CSD) using cardiac meta\u2010iodobenzylguanidine <jats:styled-content style=\"fixed-case\">(<\/jats:styled-content>MIBG) uptake and the presence of rapid eye movement sleep behavior disorder (RBD), assessed using a questionnaire (PD with CSD and RBD indicating the body\u2010first subtype).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 55 patients with PD were categorized into body\u2010first PD (<jats:italic>n<\/jats:italic>\u2009=\u200937) and brain\u2010first PD (<jats:italic>n<\/jats:italic>\u2009=\u200918) groups. The body\u2010first PD group exhibited smaller voiding volume and first desire volume (FDV) than the brain\u2010first PD group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 in both). Also, the body\u2010first PD group had higher OABSS and IPSS scores, and higher prevalence of overactive bladder diagnosed by OABSS, compared to the brain\u2010first PD group. In multiple linear regression, cardiac MIBG uptake was positively correlated with FDV and voiding volume and\u00a0negatively correlated with OABSS and IPSS (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 in all).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with the body\u2010first PD subtype exhibited more pronounced overactive bladder symptoms and impaired storage function in the early stage of disease. Additionally, cardiac MIBG was significantly associated with urological dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16497","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T08:29:09Z","timestamp":1727684949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Urodynamic study and its correlation with cardiac meta\u2010iodobenzylguanidine <scp>(MIBG)<\/scp> in body\u2010first and brain\u2010first subtypes of Parkinson's disease"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4397-6612","authenticated-orcid":false,"given":"Min Seung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology, Dongtan Sacred Heart Hospital Hallym University  Hwaseong Gyeonggi Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong 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