{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T03:26:12Z","timestamp":1770521172340,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016366","name":"V\u0161eobecn\u00e1 Fakultn\u00ed Nemocnice v Praze","doi-asserted-by":"publisher","award":["MH CZ \u2010 DRO \u2010 VFN00064165"],"award-info":[{"award-number":["MH CZ \u2010 DRO \u2010 VFN00064165"]}],"id":[{"id":"10.13039\/501100016366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Dysfunction of the airway defence system in Huntington's disease (HD) is a significant but often overlooked problem. Although expiratory muscle strength training (EMST) is frequently utilized in cough effectiveness treatment, its specific impact in HD patients has not yet been explored. This study investigated the effects of EMST on voluntary peak cough flow (vPCF) in HD patients and evaluated the retention of potential gains post\u2010intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective case\u2010controlled trial, 29 HD patients completed an 8\u2010week wait\u2010to\u2010start period, which served to identify the natural development of expiratory muscle strength and vPCF. This was followed by 8\u2009weeks of EMST training and an additional 8\u2009weeks of follow\u2010up. The study's outcome parameters, vPCF and maximum expiratory pressure (MEP), were measured against those of age\u2010 and sex\u2010matched healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Huntington's disease patients had significantly lower MEP (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and vPCF (<jats:italic>p<\/jats:italic>\u2009=\u20090.012) compared to healthy controls at baseline. Following the EMST, significant improvements in MEP (<jats:italic>d<\/jats:italic>\u2009=\u20091.39, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and vPCF (<jats:italic>d<\/jats:italic>\u2009=\u20090.77, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) were observed, with HD patients reaching the cough performance levels of healthy subjects. However, these gains diminished during the follow\u2010up, with a significant decline in vPCF (<jats:italic>d<\/jats:italic>\u2009=\u2009\u22120.451, <jats:italic>p<\/jats:italic>\u2009=\u20090.03) and in MEP (<jats:italic>d<\/jats:italic>\u2009=\u2009\u22120.71; <jats:italic>p<\/jats:italic>\u2009=\u20090.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Expiratory muscle strength training improves expiratory muscle strength and voluntary cough effectiveness in HD patients, but an ongoing maintenance programme is necessary to sustain the improvements.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16500","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T05:33:44Z","timestamp":1727674424000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The impact of expiratory muscle strength training on voluntary cough effectiveness in Huntington's disease"],"prefix":"10.1111","volume":"31","author":[{"given":"Romana","family":"Konvalinkova","sequence":"first","affiliation":[{"name":"Department of Neurology and Centre of Clinical Neuroscience General University Hospital and First Faculty of Medicine, Charles University  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2215-0272","authenticated-orcid":false,"given":"Martin","family":"Srp","sequence":"additional","affiliation":[{"name":"Department of Neurology and Centre of Clinical Neuroscience General University Hospital and First Faculty of Medicine, Charles University  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristyna","family":"Doleckova","sequence":"additional","affiliation":[{"name":"Department of Neurology and Centre of Clinical Neuroscience General University Hospital and First Faculty of Medicine, Charles University  Prague Czech 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