{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T12:43:21Z","timestamp":1776861801507,"version":"3.51.2"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["CS\/14\/4\/30972"],"award-info":[{"award-number":["CS\/14\/4\/30972"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011330","name":"Nottingham University Hospitals NHS Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000364","name":"Stroke Association","doi-asserted-by":"publisher","award":["SA L\u2010SMP 18\/1000"],"award-info":[{"award-number":["SA L\u2010SMP 18\/1000"]}],"id":[{"id":"10.13039\/501100000364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Ambulance trials assessing interventions in suspected stroke patients will recruit patients with currently active symptoms that will resolve into transient ischaemic attack (TIA). The safety and efficacy of glyceryl trinitrate (GTN) in the pre\u2010specified subgroup of patients with TIA in the Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke Trial 2 (RIGHT\u20102) was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>RIGHT\u20102 was a pre\u2010hospital\u2010initiated multicentre randomized sham\u2010controlled blinded\u2010endpoint trial that randomized patients with presumed ultra\u2010acute stroke within 4\u2009h of symptom onset to transdermal GTN or sham. Final diagnosis was determined by site investigators. The primary outcome was a shift in modified Rankin Scale (mRS) scores at 90\u2009days analysed using ordinal logistic regression reported as adjusted common odds ratio with 95% confidence intervals (CIs). Secondary outcomes included death or dependence (mRS &gt;2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 109 of 1149 (9.5%) patients had a final diagnosis of TIA (GTN 57, sham 52) with mean age 73 (SD 13) years, 19 (17.4%) had pre\u2010morbid mRS &gt;2, and onset to randomization was 80 min (interquartile range 49, 105). GTN lowered blood pressure by 7.4\/5.2\u2009mmHg compared with sham by hospital arrival. At day 90, GTN had no effect on shift in mRS scores (common odds ratio for increased dependence 1.47, 95% CI 0.70\u20133.11) but was associated with increased death or dependence (mRS &gt;2): GTN 29 (51.8%) versus sham 23 (46.9%), odds ratio 3.86 (95% CI 1.09\u201313.59).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pre\u2010hospital ultra\u2010acute transdermal GTN did not improve overall functional outcome in patients with investigator\u2010diagnosed TIA compared with sham treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16502","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T05:40:44Z","timestamp":1728625244000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pre\u2010hospital transdermal glyceryl trinitrate for transient ischaemic attack: Data from the <scp>RIGHT<\/scp>\u20102 trial"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2604-4410","authenticated-orcid":false,"given":"Jason P.","family":"Appleton","sequence":"first","affiliation":[{"name":"Stroke Nottingham University Hospitals NHS Trust  Nottingham UK"},{"name":"Stroke Trials Unit, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Dixon","sequence":"additional","affiliation":[{"name":"Stroke Trials Unit, School of Medicine University of Nottingham  Nottingham UK"},{"name":"East Midlands Ambulance Service NHS Trust  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4472-1999","authenticated-orcid":false,"given":"Lisa J.","family":"Woodhouse","sequence":"additional","affiliation":[{"name":"Stroke Trials Unit, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7248-4863","authenticated-orcid":false,"given":"Craig S.","family":"Anderson","sequence":"additional","affiliation":[{"name":"George Institute for Global Health, Faculty of Medicine University of New South Wales  Sydney New South Wales Australia"},{"name":"George Institute Peking University Health Science Center  Beijing China"},{"name":"Neurology Department, Royal Prince Alfred Hospital Sydney Health Partners  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Ankolekar","sequence":"additional","affiliation":[{"name":"Department of Neurology King's College Hospital London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley","family":"Cala","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J.","family":"England","sequence":"additional","affiliation":[{"name":"Stroke Trials Unit, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Godolphin","sequence":"additional","affiliation":[{"name":"MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kailash","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Stroke Nottingham University Hospitals NHS Trust  Nottingham UK"},{"name":"Stroke Trials Unit, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant","family":"Mair","sequence":"additional","affiliation":[{"name":"Centre for Clinical Brain Sciences, Edinburgh Imaging and UK Dementia Research Institute University of Edinburgh  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9535-022X","authenticated-orcid":false,"given":"Keith W.","family":"Muir","sequence":"additional","affiliation":[{"name":"Institute of Neurology and Psychology University of Glasgow  Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Potter","sequence":"additional","affiliation":[{"name":"Bob Champion Research and Education Building University of East Anglia  Norwich UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris I.","family":"Price","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute Newcastle University  Newcastle UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Randall","sequence":"additional","affiliation":[{"name":"Neurology Leeds Teaching Hospitals NHS Trust  Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thompson G.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre University of Leicester  Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Roffe","sequence":"additional","affiliation":[{"name":"Stroke Research in Stoke, School of Medicine Keele University  Stoke\u2010on\u2010Trent UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Rothwell","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4312-4778","authenticated-orcid":false,"given":"Else Charlotte","family":"Sandset","sequence":"additional","affiliation":[{"name":"Department of Neurology Oslo University Hospital  Oslo Norway"},{"name":"Research and Development Norwegian Air Ambulance Foundation  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey L.","family":"Saver","sequence":"additional","affiliation":[{"name":"Department of Neurology and Comprehensive Stroke Center David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Niroshan","family":"Siriwardena","sequence":"additional","affiliation":[{"name":"Community and Health Research Unit University of Lincoln  Lincoln UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna M.","family":"Wardlaw","sequence":"additional","affiliation":[{"name":"Centre for Clinical Brain Sciences, Edinburgh Imaging and UK Dementia Research Institute University of Edinburgh  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikola","family":"Sprigg","sequence":"additional","affiliation":[{"name":"Stroke Nottingham University Hospitals NHS Trust  Nottingham UK"},{"name":"Stroke Trials Unit, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip M.","family":"Bath","sequence":"additional","affiliation":[{"name":"Stroke Nottingham University Hospitals NHS Trust  Nottingham UK"},{"name":"Stroke Trials Unit, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the RIGHT\u20102 Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-023-06910-w"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30194-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493017724627"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/2396987318756696"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493018816451"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.571562"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61121-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108784"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.026389"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008881"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00333-7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2022-001634"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12873-021-00560-x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/23969873211012133"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.49628"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.16502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T04:45:55Z","timestamp":1757565955000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.16502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,11]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/ene.16502"],"URL":"https:\/\/doi.org\/10.1111\/ene.16502","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,11]]},"assertion":[{"value":"2024-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16502"}}