{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:00:49Z","timestamp":1784296849257,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Chlormadinone acetate (CMA) is a synthetic progestin for which cases of intracranial meningioma have been reported following prolonged exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>An observational cohort study was conducted based on the French national health data system. Women aged 10\u201070 years and who started CMA between 2007 and 2017 were included. Participants were considered to be exposed if they had received a cumulative dose &gt;360\u2009mg of CMA during the first 6\u2009months and very slightly exposed (control group) when they had received a cumulative dose \u2264360\u2009mg. The outcome was surgery or radiotherapy for one or more intracranial meningioma(s). Poisson models assessed the relative risk (RR) of meningioma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 828,499 women were included: 469,976 in the exposed group (mean age 39.1\u2009years, SD 10.1) and 358,523 in the control group (38.3\u2009years, SD 11.0). Surgery or radiotherapy for intracranial meningioma between 2007 and 2017 was recorded for 164 and 104 women in the exposed and control groups, respectively. The incidence of meningioma was 18.5 and 6.8 per 100,000 person\u2010years for the exposed and control groups respectively (crude RR\u2009=\u20092.7, 95% confidence interval [CI] 2.1\u20133.5; age\u2010adjusted RR\u2009=\u20093.1, 95% CI 2.4\u20134.0). Meningioma incidence reached almost 47 cases\/100,000 person\u2010years in the most exposed group (&gt;8.64\u2009g), giving an age\u2010adjusted RR of 6.9, 95% CI 5.1\u20139.2, relative to the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A strong dose\u2013effect relationship was observed between prolonged use of CMA and risk of meningiomas. As with other progestogens, meningiomas associated with CMA are more likely to be found at the base of the skull.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16505","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T11:45:32Z","timestamp":1730893532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prolonged use of chlormadinone acetate and risk of intracranial meningioma: A population\u2010based cohort study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8079-4263","authenticated-orcid":false,"given":"No\u00e9mie","family":"Roland","sequence":"first","affiliation":[{"name":"EPI\u2010PHARE Scientific Interest Group (French National Agency for the Safety of Medicines and Health Products, and French National Health Insurance)  Saint\u2010Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9066-9100","authenticated-orcid":false,"given":"Pierre","family":"Nguyen","sequence":"additional","affiliation":[{"name":"EPI\u2010PHARE Scientific Interest Group (French National Agency for the Safety of Medicines and Health Products, and French National Health Insurance)  Saint\u2010Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6697-8023","authenticated-orcid":false,"given":"Anke","family":"Neumann","sequence":"additional","affiliation":[{"name":"EPI\u2010PHARE Scientific Interest Group (French National Agency for the Safety of Medicines and Health Products, and French National Health Insurance)  Saint\u2010Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0921-5142","authenticated-orcid":false,"given":"L\u00e9a","family":"Hoisnard","sequence":"additional","affiliation":[{"name":"EpiDermE Epidemiology in Dermatology and Evaluation of Therapeutics, EA7379 Paris Est Cr\u00e9teil University (UPEC)  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4759-0389","authenticated-orcid":false,"given":"Thibault","family":"Passeri","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Lariboisi\u00e8re University Hospital, Paris\u2010Cit\u00e9 University, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9434-248X","authenticated-orcid":false,"given":"Lise","family":"Duranteau","sequence":"additional","affiliation":[{"name":"Department of Medical Gynaecology Bic\u00eatre Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris, Paris Saclay University  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7674-7192","authenticated-orcid":false,"given":"Jo\u00ebl","family":"Coste","sequence":"additional","affiliation":[{"name":"Biostatistics and Epidemiology Unit Cochin Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"},{"name":"Paris Cit\u00e9 University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9124-2395","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Froelich","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Lariboisi\u00e8re University Hospital, Paris\u2010Cit\u00e9 University, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-4217","authenticated-orcid":false,"given":"Mahmoud","family":"Zureik","sequence":"additional","affiliation":[{"name":"EPI\u2010PHARE Scientific Interest Group (French National Agency for the Safety of Medicines and Health Products, and French National Health Insurance)  Saint\u2010Denis France"},{"name":"Versailles St\u2010Quentin\u2010en\u2010Yvelines University  Montigny le Bretonneux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8687-9092","authenticated-orcid":false,"given":"Alain","family":"Weill","sequence":"additional","affiliation":[{"name":"EPI\u2010PHARE Scientific Interest Group (French National Agency for the Safety of Medicines and Health Products, and French National Health Insurance)  Saint\u2010Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n37"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15423"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.100928"},{"key":"e_1_2_10_5_1","unstructured":"JORF. 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