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We aimed to study the risk factors for intensive care unit admission for MG exacerbation and myasthenic crisis (MC) and the prognosis of people with MG (pwMG) thereafter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study investigated patients in the Helsinki and Uusimaa hospital district during the years 2008\u20132021. PwMG (International Classification of Diseases, 10<jats:sup>th<\/jats:sup> revision code G70.0) were identified through a data repository search, followed by a chart review of patient records. Risk factors for intensive care due to MG exacerbation were evaluated as compared with the patients only treated in the outpatient clinic and those treated in the neurological ward for MG exacerbation. The outcomes of patients in intensive care for any reason were also compared with those of patients in intensive care for exacerbation of <jats:italic>bronchial asthma<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 577 pwMG, 35 (6.1%) needed intensive care for MG within a median of 5.3\u2009months from diagnosis. The mean (\u00b1SD) age at MG diagnosis was higher in the intensive care group (60.5 [\u00b116.1] years) compared to the outpatient (48.3 [\u00b120.9] years; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and neurological ward groups (53.4 [\u00b120.8] years; <jats:italic>p<\/jats:italic>\u2009=\u20090.044). Thymoma (odds ratio [OR] 4.8, 95% confidence interval [CI] 1.19\u201319.43; <jats:italic>p<\/jats:italic>\u2009=\u20090.028) and female sex (OR 2.1, 95% CI 1.02\u20134.48; <jats:italic>p<\/jats:italic>\u2009=\u20090.045) were independent risk factors for intensive care. In\u2010hospital mortality was 4% for MC patients. Six\u2010month mortality after intensive care for MG exacerbation (14.3%) was twice that for asthma exacerbation (7.7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study shows an increased risk of intensive care treatment for patients with late\u2010onset MG, female sex or thymoma, occurring usually within 6\u2009months from diagnosis, which emphasises the importance of early treatment choices.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16522","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T05:42:50Z","timestamp":1729575770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Intensive care due to myasthenia gravis: Risk factors and prognosis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3959-6257","authenticated-orcid":false,"given":"Chris","family":"Myllynen","sequence":"first","affiliation":[{"name":"Department of Neurosciences University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anni","family":"Tuulasvaara","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of Helsinki  Helsinki Finland"},{"name":"Department of Neurology, Brain Center Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari","family":"Atula","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of Helsinki  Helsinki Finland"},{"name":"Department of Neurology, Brain Center Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0104-2849","authenticated-orcid":false,"given":"Sini M.","family":"Laakso","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of Helsinki  Helsinki Finland"},{"name":"Department of Neurology, Brain Center Helsinki University Hospital  Helsinki Finland"},{"name":"Translational Immunology Research Program University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00145-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00212"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00297-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827b907b"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27832"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008688"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a41211"},{"key":"e_1_2_10_9_1","article-title":"Epidemiology of myasthenia gravis in Denmark, Finland and Sweden: a population\u2010based observational study","volume":"95","author":"Vissing J","year":"2024","journal-title":"J Neurol Neurosurg Psychiatry Published Online"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26689"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.04.045"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2017.06.009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcn152"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.3.2.115"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02448-4"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2015.03.018"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-014-1659-y"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)01595-2"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.06.054"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06379-z"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12115"},{"key":"e_1_2_10_22_1","unstructured":"HUS: s\u00e4hk\u00f6iset palvelut tutkijalle.2022. 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