{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:00:10Z","timestamp":1790650810387,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Levodopa\u2013entacapone\u2013carbidopa intestinal gel (LECIG) infusion is a recently developed device\u2010aided therapy for advanced Parkinson disease (PD) patients. The aim of this study was to report real\u2010world evidence about the effectiveness, tolerability, and safety of LECIG in PD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter observational retrospective study of the first patients who initiated LECIG in Spain was performed. All neurologists with an experience of at least two patients treated until 30 March 2024 were invited to participate. Data about effectiveness and safety from the medical records (V0, pre\u2010LECIG; V1, initiation of LECIG; V2, post\u2010LECIG follow\u2010up) with a total of 246 variables were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010three PD patients (61.6% males, 70.1\u2009\u00b1\u20099.1\u2009years old) from 21 Spanish centers with a mean disease duration of 14.4\u2009\u00b1\u20096.3\u2009years (range\u2009=\u20095\u201331) were included. Twenty\u2010six patients (35.6%) were switched directly from levodopa\u2013carbidopa intestinal gel. The mean exposure to LECIG was 177.3\u2009\u00b1\u2009110.5\u2009days (range\u2009=\u20097\u2013476). The mean daily OFF time decreased from 5.2\u2009\u00b1\u20093 (pre\u2010LECIG) to 1.9\u2009\u00b1\u20091.8 (post\u2010LECIG; <jats:italic>n<\/jats:italic>\u2009=\u200966, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Global improvement was observed in &gt;85% of the patients. No significant change was detected in the levodopa equivalent daily dose from V0 to V2. Only 7% received 24\u2010h infusion, and 24.7% required more than one cartridge per day at V2. Thirty\u2010four patients (46.6%) had at least one adverse event related to LECIG and\/or the device system. Five patients (6.8%) discontinued LECIG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LECIG was safe and effective in advanced PD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16535","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T16:40:07Z","timestamp":1730133607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effectiveness and safety of levodopa\u2013entacapone\u2013carbidopa infusion in Parkinson disease: A real\u2010world data study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3126-5111","authenticated-orcid":false,"given":"Diego","family":"Santos\u2010Garc\u00eda","sequence":"first","affiliation":[{"name":"Department of Neurology Hospital Universitario de A Coru\u00f1a, Complejo Hospitalario Universitario de A Coru\u00f1a  A Coru\u00f1a Spain"},{"name":"Grupo de Investigaci\u00f3n en 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