{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T01:37:36Z","timestamp":1782437856373,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Limited options exist for migraine prevention after stopping anti\u2010calcitonin gene\u2010related peptide monoclonal antibodies. A systematic review examining the benefits of switching between different classes (ligand vs. receptor monoclonal antibody) is essential, alongside well\u2010designed real\u2010world studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cohort study 67 patients were included, who discontinued their first treatment with erenumab or fremanezumab. Patients (<jats:italic>n<\/jats:italic>\u2009=\u200931) switched to another monoclonal antibody class within 3\u2009months, whilst those in the control group (<jats:italic>n<\/jats:italic>\u2009=\u200936) received standard care. Allocation to either group relied largely on the availability of alternative monoclonal antibody treatments, introducing pseudo\u2010random allocation. Changes in monthly migraine days were compared between groups 3 months post\u2010discontinuation of the first monoclonal antibody or initiation of a different monoclonal antibody class. A multivariate regression model was conducted that accounted for potential confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The groups were comparable at baseline and poor treatment response was the main reason for treatment discontinuation of the first monoclonal antibody. The switching cohort experienced a reduction of 3.9 monthly migraine days (95% confidence interval \u22126.4, \u22121.3, <jats:italic>p<\/jats:italic>\u2009=\u20090.004) compared with the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transitioning to a different anti\u2010calcitonin gene\u2010related peptide monoclonal class yields reduction in monthly migraine days compared to returning to standard care for patients with inadequate initial treatment response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16542","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T13:29:37Z","timestamp":1732800577000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Switching from ligand to receptor anti\u2010calcitonin gene\u2010related peptide (<scp>CGRP<\/scp>) antibodies or vice versa in non\u2010responders: A controlled cohort study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3558-8065","authenticated-orcid":false,"given":"Nancy","family":"van Veelen","sequence":"first","affiliation":[{"name":"Department of Neurology Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8999-0087","authenticated-orcid":false,"given":"Britt W. 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