{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T01:45:49Z","timestamp":1779155149319,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD21\/0006\/0010"],"award-info":[{"award-number":["RD21\/0006\/0010"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Knowledge about the prevalence of atrial fibrillation (AF) in young stroke patients, as well as its associated factors and outcomes, is scarce. Our objective was to analyse it.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of the Spain Nationwide Minimum Basic Data Set (MBDS)\u00a0(2016\u20132020), including ischaemic stroke (IS) patients aged 18 and 50\u2009years, was conducted. Multivariate analyses were conducted to identify factors related to AF diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Amongst 11,615 young IS patients, 426 (3.7%) had AF. Patients with AF were older (median age 45, interquartile range 42\u201348 vs. 44, interquartile range 40\u201347\u2009years, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and displayed more incapacitating symptoms, higher in\u2010hospital complications and were less often discharged home (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Multivariate analyses showed that older age (odds ratio [OR] 1.053, 95% confidence interval [CI] 1.032\u20131.074), obstructive sleep apnoea (OR 1.508, 95% CI 1.018\u20132.233), hyperthyroidism (OR 3.741, 95% CI 1.798\u20137.783), valvular heart disease (OR 6.094, 95% CI 4.261\u20138.716), congenital (OR 2.386, 95% CI 1.146\u20134.969) and non\u2010congenital (OR 4.446, 95% CI 3.149\u20136.278) cardiopathies and heart failure (OR 3.098, 95% CI 1.905\u20135.037) were independently associated with higher probability of AF, whereas female gender (OR 0.647, 95% CI 0.516\u20130.812), diabetes mellitus (0.487, 95% CI 0.339\u20130.699), smoking (OR 0.617, 95% CI 0.501\u20130.759), patent foramen ovale (OR 0.210, 95% CI 0.111\u20130.396) and arterial dissection (OR 0.294, 95% CI 0.130\u20130.668) were associated with a lower probability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In young IS patients, AF is associated with more in\u2010hospital complications and disabling strokes. These findings emphasize the need to recognize AF in this demographic group, especially in patients with risk factors like hyperthyroidism and cardiomyopathies. Clinicians should assess these risk factors to ensure timely diagnosis and management of AF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16555","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T13:19:43Z","timestamp":1732799983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Atrial fibrillation in young stroke patients: Associated factors and outcomes in a nationwide analysis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4902-4755","authenticated-orcid":false,"given":"Tania","family":"Garrido\u2010Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Neurology, Stroke Centre Torrec\u00e1rdenas University Hospital  Almer\u00eda Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Amaya\u2010Pascasio","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Centre Torrec\u00e1rdenas University Hospital  Almer\u00eda Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Quesada\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Centre Torrec\u00e1rdenas University Hospital  Almer\u00eda Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Arjona\u2010Padillo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Centre Torrec\u00e1rdenas University Hospital  Almer\u00eda Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Manuel","family":"Garc\u00eda\u2010Torrecillas","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine and Biomedical Research Unit Torrec\u00e1rdenas University Hospital  Almer\u00eda Spain"},{"name":"Biomedical Research Institute Ibs  Granada Spain"},{"name":"Networked Biomedical Research Center in Epidemiology and Public Health (CIBERESP)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Mart\u00ednez\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Centre Torrec\u00e1rdenas University Hospital  Almer\u00eda Spain"},{"name":"Department of Nursing, Physiotherapy and Medicine, Faculty of Health Science University of Almer\u00eda  Almeria Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12154999"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0211-139x(08)71163-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2019.05.008"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrleng.2022.07.006"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030812"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad615"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1474515114552043"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.105998"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12187"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000332030"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.248"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.98.10.946"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpc.2020.100085"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12072600"},{"key":"e_1_2_11_16_1","unstructured":"Ministry of Health. Health in data\u2014Discharge Registry of the Hospitals of the National Health System. CMBD.https:\/\/www.sanidad.gob.es\/estadEstudios\/estadisticas\/cmbdhome.htm"},{"key":"e_1_2_11_17_1","unstructured":"BOE\u2010A\u20102015\u20101235. Royal Decree 69\/2015 of February 6 regulating the Registry of Specialized Healthcare Activity.https:\/\/www.boe.es\/buscar\/act.php?id=BOE\u2010A\u20102015\u20101235"},{"key":"e_1_2_11_18_1","unstructured":"The Web's Free.ICD\u201010\u2010CM\/PCS Medical Coding Reference.2024https:\/\/www.icd10data.com\/"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.529883"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2015.019"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/23969873221099478"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.309732"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2021.06.010"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2020.02.001"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007533"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13050768"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.46791"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccep.2020.11.005"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmclc.2015.04.007"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028753"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022560"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.10.011"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-0229"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/976976"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-308120"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.09.045"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.10.009"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2019.01.001"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-016-4463-z"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107299"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semerg.2020.12.003"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-8865-0"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2021.09.001"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19459"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135834"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.16555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T05:16:11Z","timestamp":1737954971000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.16555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,28]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/ene.16555"],"URL":"https:\/\/doi.org\/10.1111\/ene.16555","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,28]]},"assertion":[{"value":"2024-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16555"}}