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Here, we applied the abbreviated version of the Comprehensive Affect Testing System (CATS\u2010A) battery to Italian FTD cases and healthy controls (HC) to provide cut\u2010offs of emotional dysfunction in the whole group and in different FTD clinical syndromes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred thirty\u2010nine FTD patients (60 behavioural variant [bvFTD],13 semantic behavioural variant of FTD [sbvFTD], 28 progressive supranuclear palsy [PSP], 21 semantic [svPPA] and 17 nonfluent [nfvPPA] variants of primary progressive aphasia) and 116 HC were administered the CATS\u2010A, yielding an Affective Recognition Quotient (ARQ), which was used as outcome measure. Age\u2010 and education\u2010adjusted, regression\u2010based norms were derived in HC. In patients, the ARQ was assessed for its internal reliability, factorial validity and construct validity by testing its association with another social cognition paradigm, the Story\u2010Based Empath Task (SET). The diagnostic accuracy of the ARQ in discriminating patients from HC, genetic cases from HC and patient groups among each other was tested via ROC analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the whole FTD cohort, CATS\u2010A proved to be underpinned by a mono\u2010component factor (51.1%) and was internally consistent (McDonald's \u03c9\u2009=\u20090.76). Moreover, the ARQ converged with the SET (<jats:italic>r<\/jats:italic>(122)\u2009=\u20090.50; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and optimally discriminated HC from both the whole cohort (AUC\u2009=\u20090.89) and each clinical syndrome (AUC range: 0.83\u20130.92). Conversely, CATS\u2010A subtests were able to distinguish patient groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The ARQ score from the CATS\u2010A distinguishes FTD clinical syndromes from HC with high accuracy, making it an excellent tool for immediate use in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16578","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T06:20:30Z","timestamp":1733379630000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A common marker of affect recognition dysfunction in the <scp>FTD<\/scp> spectrum of disorders"],"prefix":"10.1111","volume":"32","author":[{"given":"Elisa","family":"Canu","sequence":"first","affiliation":[{"name":"Neuroimaging Research Unit, Division of Neuroscience IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Neurology Unit IRCCS San Raffaele Scientific Institute 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