{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:01:35Z","timestamp":1791820895487,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["374031971 \u2010 TRR 240"],"award-info":[{"award-number":["374031971 \u2010 TRR 240"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["413657723"],"award-info":[{"award-number":["413657723"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1279"],"award-info":[{"award-number":["SFB1279"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed to investigate the prognostic role of \u03b2\u2010synuclein in comparison to that of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) for predicting functional outcome after acute ischemic stroke (AIS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured serum concentrations of \u03b2\u2010synuclein, NfL and GFAP 24\u2009h after hospital admission in 213 consecutive patients with moderate\u2010to\u2010severe AIS. We investigated the association between serum biomarkers and radiological\/clinical characteristics, 3\u2010months mortality and functional outcome on the modified Rankin Scale (mRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 213 patients with AIS [mean age: 76.1 (\u00b112.5) years, 53.1% males, median NIHSS score on admission: 13 (IQR: 9\u201317)], higher levels of \u03b2\u2010synuclein, NfL and GFAP were associated with higher NIHSS scores and with lower Alberta Stroke Program CT Score (ASPECTS) points on admission. Serum \u03b2\u2010synuclein levels was significantly correlated with NfL (rho\u2009=\u20090.715, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and GFAP concentrations (rho\u2009=\u20090.684, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The inclusion of serum \u03b2\u2010synuclein significantly improved the accuracy of prediction models without biomarkers for overall mortality (AUC: 0.836 vs. 0.752, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and mRS 3\u20136 vs. 0\u20132 (AUC: 0.812 vs. 0.624, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Combination models with NfL and\/or GFAP showed a similar accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum \u03b2\u2010synuclein may be used to assess synaptic damage\/dysfunction and to predict 3\u2010months clinical outcomes in patients with AIS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16581","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T13:54:41Z","timestamp":1734962081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prognostic serum biomarkers of synaptic, neuronal and glial injury in patients with acute ischemic stroke of the anterior circulation"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1328-3620","authenticated-orcid":false,"given":"Lorenzo","family":"Barba","sequence":"first","affiliation":[{"name":"Department of Neurology Martin\u2010Luther\u2010University of Halle\u2010Wittenberg  Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5893-1196","authenticated-orcid":false,"given":"Christoph","family":"Vollmuth","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital W\u00fcrzburg (UKH)  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Halbgebauer","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Ulm  Ulm Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE e.V.)  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