{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:59:20Z","timestamp":1790650760885,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Levodopa\u2013entacapone\u2013carbidopa intestinal gel (LECIG) was introduced on the Swedish market in 2019. The therapy is aimed at patients with Parkinson's disease (PD) with fluctuations and dyskinesias. Long\u2010term efficacy and safety data are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the efficacy, tolerability, and safety of LECIG in regular clinical practice for Parkinson's disease in Sweden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Real\u2010world data were collected from the Swedish registry for Parkinson's disease (ParkReg) for all patients reported to receive LECIG during the period from 2019 until 31 August 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 150 patients were identified. Sixty\u2010one (41%) of 150 patients were females. At the start of treatment, the median age was 73\u2009years (range: 43\u201386). The median duration since motor symptoms onset was 17\u2009years (IQR: 9). Fifty (33%) of 150 patients switched from another device\u2010assisted therapy, mostly LCIG (39 patients).<\/jats:p><jats:p>Reported complications were mainly related to PEG\u2010J tube and stoma (30%). Twenty (13.3%) of 150 patients discontinued LECIG and 11 (7.3%) patients died while on LECIG.<\/jats:p><jats:p>The Parkinson KinetiGraph scores for bradykinesia, dyskinesia, fluctuations, tremor, and immobility for 53 patients during LECIG showed good therapy control. The median (IQR) p\u2010Hcy during LECIG was 12 (4.6) \u03bcmol\/L (<jats:italic>n<\/jats:italic>\u2009=\u200944). The median (IQR) PDQ\u20108 summary index during LECIG was 31 (17) (<jats:italic>n<\/jats:italic>\u2009=\u200952). The median (IQR) EQ5D during LECIG was 0.62 (0.32) (<jats:italic>n<\/jats:italic>\u2009=\u200941).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Data from ParkReg covering 150 patients over 3\u2009years show LECIG to be an effective and safe device\u2010aided therapy for advanced PD. However, the long\u2010term efficacy and tolerability of LECIG need to be further investigated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16582","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T13:55:23Z","timestamp":1733234123000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Levodopa\u2013entacapone\u2013carbidopa intestinal gel: Data from the Swedish national registry for Parkinson's disease"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7139-8561","authenticated-orcid":false,"given":"Mezin","family":"\u00d6thman","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Neurology Uppsala University  Uppsala Sweden"},{"name":"Department of Neurology Uppsala University Hospital  Uppsala 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