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We included 168 age\u2010matched healthy controls, half female (f\u2010HC) and half male (m\u2010HC). We compared brain metabolism of males and females separately for ALS and HC, including age as covariate. A differential network analysis was performed to evaluate brain connectivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>M\u2010ALS showed relative hypometabolism of bilateral medial frontal, parietal and occipital cortices, and left temporal cortex, compared to f\u2010ALS. In node\u2010wise comparison, f\u2010ALS showed significantly higher connectivity in right middle cingulate cortex and left superior and medial frontal gyrus. In HC we did not find any sex\u2010related differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sex resulted a major determinant of brain metabolism and connectivity in ALS patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16588","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T11:26:51Z","timestamp":1733830011000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sex\u2010related differences in amyotrophic lateral sclerosis: A 2\u2010[<scp><sup>18<\/sup>F<\/scp>]<scp>FDG<\/scp>\u2010<scp>PET<\/scp> study"],"prefix":"10.1111","volume":"32","author":[{"given":"Antonio","family":"Canosa","sequence":"first","affiliation":[{"name":"ALS Centre, \u2018Rita Levi Montalcini\u2019 Department of Neuroscience University of Turin  Turin Italy"},{"name":"Azienda Ospedaliero\u2010Universitaria Citt\u00e0 della Salute e della Scienza di Torino Neurology 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