{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:25:59Z","timestamp":1788193559794,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Migraine is a debilitating neurological disease with a multifaceted pathophysiology. Pre\u2010existing comorbidities may influence the risk of developing migraine. This review and meta\u2010analysis aim to present a comprehensive overview of the known comorbidities predisposing individuals to new migraine onset, thereby improving our understanding of the respective diseases' interactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of PubMed and EMBASE identified studies on pre\u2010existing comorbidities as risk factors for new migraine onset. We performed three\u2010level meta\u2010analyses employing restricted maximum likelihood estimation to calculate pooled risk ratios (pRR). Subgroup and sensitivity analyses were conducted to assess the robustness of the data. Risk of bias (RoB) was assessed with the Quality in Prognostic Studies Tool. This review was pre\u2010registered on Prospero (CRD42024501140).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From a total of 17,330 records, we identified 38 studies, encompassing 124 effect sizes from 58 exposures. Most studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928, 74%) had a low RoB. Heterogeneity was high (&gt;90%), primarily due to within\u2010study differences (&gt;50%), and was not significantly impacted by moderator tests or the exclusion of outliers. We found significantly increased risks for migraine onset associated with prior atopic conditions [pRR\u2009=\u20091.53 (1.15, 2.03)], psychiatric or psychological disorders [pRR\u2009=\u20092.63 (1.79, 3.85)], sleep disorders [pRR\u2009=\u20091.89 (1.26, 2.85)], and cardiovascular conditions [pRR\u2009=\u20091.72 (1.07, 2.76)].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pre\u2010existing atopic, psychiatric, sleep, and cardiovascular conditions are significantly associated with new migraine onset, likely due to shared genetic predisposition and mediating factors like stress and inflammation. Future research should focus on these associations to advance targeted prevention and treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.16590","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T05:26:57Z","timestamp":1741757217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comorbidities as risk factors for migraine onset: A systematic review and three\u2010level meta\u2010analysis"],"prefix":"10.1111","volume":"32","author":[{"given":"Maria","family":"Terhart","sequence":"first","affiliation":[{"name":"Department of Neurology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2057-7184","authenticated-orcid":false,"given":"Lucas Hendrik","family":"Overeem","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Doctoral Program, International Graduate Program Medical Neurosciences Humboldt Graduate School  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ja Bin","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8527-0725","authenticated-orcid":false,"given":"Uwe","family":"Reuter","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, 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