{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:21:41Z","timestamp":1791231701211,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to characterize hereditary spastic paraplegias (HSP) patients' urodynamic profiles and development of bladder symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a multicentric retrospective study which included patients presenting with bladder disorders. We reviewed medical and urodynamic records in individuals with HSP and recorded age at onset of gait and bladder disorders, disability stage at the time of urodynamic assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 122 participants. They were mostly men (<jats:italic>n<\/jats:italic>\u2009=\u200974) with a median age at interview of 54.6\u2009\u00b1\u200913.0 [25\u201376] years. The underlying genetic cause was identified in 70% of participants, with 54 heterozygous mutations in <jats:italic>SPAST,<\/jats:italic> followed by 7 <jats:italic>SPG11<\/jats:italic> and 6 <jats:italic>SPG7<\/jats:italic>. The age at onset of motor disorder was significantly younger than for the beginning of bladder dysfunction (49.3 vs. 29.7\u2009years\u2010old, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Detrusor overactivity was present in most participants (72.1%), followed by detrusor\u2010sphincter\u2010dyssynergia (65.3%). Similar proportions were present in the <jats:italic>SPAST<\/jats:italic> group as well as the non\u2010<jats:italic>SPAST<\/jats:italic> group. The <jats:italic>SPAST<\/jats:italic> group developed urinary symptoms later than the non\u2010SPAST group as compared to the age at onset of spasticity (53.8\u2009\u00b1\u200911.3 and 44.1\u2009\u00b1\u200913.2 for the <jats:italic>SPAST<\/jats:italic> group vs. 44.1\u2009\u00b1\u200913.2 and 25.5\u2009\u00b1\u200917.3 for the non\u2010SPAST group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We have shown that the most common urodynamic pattern in HSP is detrusor overactivity associated with detrusor\u2010sphincter dyssynergia, as would be expected for upper motor neuron lesions. We assessed the temporal window of onset, showing that urinary disorders are secondary to spastic gait in HSP and particularly frequent when walking capability deteriorates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.70003","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T12:48:44Z","timestamp":1734698924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hereditary spastic paraplegias: When to expect bladder dysfunction a genetic and urodynamic study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8495-1409","authenticated-orcid":false,"given":"Pauline","family":"Lallemant\u2010Dudek","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, Paris Brain Institute (ICM Institut du Cerveau), INSERM, CNRS, Assistance Publique\u2010H\u00f4pitaux de Paris (APHP), University Hospital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"},{"name":"Sorbonne Universit\u00e9, Pediatric Physical Medicine and Rehabilitation Department Hospital Armand Trousseau  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Guillaud\u2010Bataille","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique, AP\u2010HP, GH Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9223-4925","authenticated-orcid":false,"given":"Claire","family":"Hentzen","sequence":"additional","affiliation":[{"name":"Sorbonne University, GRC 01, GREEN Group of clinical REsEarch in Neurourology, AP\u2010HP H\u00f4pital Tenon  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Joussain","sequence":"additional","affiliation":[{"name":"UMR 1179, Inserm Faculty of Medicine, Versailles Saint Quentin University, Paris Saclay Neuro\u2010Uro\u2010Andrology R. Poincare University Hospital  Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Pichon","sequence":"additional","affiliation":[{"name":"Department of Physical and Rehabilitation Medicine University Hospital Piti\u00e9\u2010Salp\u00eatri\u00e8re, APHP  Paris France"},{"name":"Sorbonne Universit\u00e9, GRC 01, GREEN Group of clinical REsEarch in Neurourology  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberte","family":"Robain","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation Sorbonne Universit\u00e9, University Hosiptal Rothschild, APHP  Paris France"},{"name":"GRC 001 GREEN Neuro\u2010Urology Research Group  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Haddad","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation Sorbonne Universit\u00e9, University Hosiptal Rothschild, APHP  Paris France"},{"name":"GRC 001 GREEN Neuro\u2010Urology Research Group  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Coarelli","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Paris Brain Institute (ICM Institut du Cerveau), INSERM, CNRS, Assistance Publique\u2010H\u00f4pitaux de Paris (APHP), University Hospital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Heinzmann","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Paris Brain Institute (ICM Institut du Cerveau), INSERM, CNRS, Assistance Publique\u2010H\u00f4pitaux de Paris (APHP), University Hospital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Denys","sequence":"additional","affiliation":[{"name":"UMR 1179, Inserm Faculty of Medicine, Versailles Saint Quentin University, Paris Saclay Neuro\u2010Uro\u2010Andrology R. 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