{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:19:08Z","timestamp":1790050748589,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Three large, randomized trials demonstrated the benefit of short\u2010term dual antiplatelet therapy (DAPT) versus monotherapy after non\u2010cardioembolic minor stroke or high\u2010risk transient ischemic attack (TIA). The aim of this study was to evaluate effects of DAPT versus monotherapy on functional outcomes and safety in a real\u2010life setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with minor stroke (NIHSS &lt;4) or high\u2010risk TIA (ABCD2 score\u2009\u22654) of non\u2010cardioembolic origin without major vessel occlusion or revascularization therapy (thrombolysis or thrombectomy) treated between 2018 and 2023 were analyzed based on a prospective nationwide stroke unit registry. Data on risk factors, stroke etiology, admission stroke severity (NIHSS), functional status at 3\u2009months (mRS), and mortality were extracted. Excellent functional outcome (mRS 0\u20131) at 3\u2009months, early neurological deterioration (END), symptomatic intracranial hemorrhage (SICH) and major extracranial bleeds were defined as study endpoints and adjusted for covariates using inverse probability of treatment weighted regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two Thousand Two Hundred Fifty\u2010four of 8546 patients with non\u2010cardioembolic minor stroke or high\u2010risk TIA received DAPT. Patients treated with DAPT had significantly more risk factors and comorbidities compared to those treated with monotherapy. After robust statistical adjustment, DAPT was significantly associated with lower occurrence of END (OR 0.50 95% CI 0.35\u20130.72), increased odds of excellent outcome at 3\u2009months (aOR 1.59; 95% CI 1.20\u20132.09) and equivalent frequencies of SICH (aOR 1.19, 95% CI 0.30\u20134.73) or major extracranial bleeding (aOR 0.84; 95% CI 0.16\u20134.56).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DAPT in non\u2010cardioembolic minor stroke or high\u2010risk TIA in a real\u2010life setting appears to be safe and associated with improved functional outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.70012","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T03:45:03Z","timestamp":1734666303000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dual antiplatelet therapy after minor strokes or high\u2010risk TIA: Evidence from the Austrian stroke 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Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Lang","sequence":"additional","affiliation":[{"name":"Sigmund Freud University Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Neurology St. John's Hospital  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3508-2176","authenticated-orcid":false,"given":"Marek","family":"Sykora","sequence":"additional","affiliation":[{"name":"Department of Neurology St. John's Hospital  Vienna Austria"},{"name":"Sigmund Freud University Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Austrian Stroke Unit Registry 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