{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:46:58Z","timestamp":1790293618105,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Patients with pre\u2010existing Parkinson's disease (PD) face higher risks of severe acute COVID\u201019 outcomes than matched controls, but long\u2010term post\u2010COVID\u201019 outcomes remain largely unknown. This study investigated clinical outcomes up to 3.5\u2009years post\u2010infection in a Bronx inner\u2010city PD population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study evaluated 3512 patients with PD in the Montefiore Health System (January 2016\u2013July 2023), which serves a large diverse population and was an epicenter of the early COVID\u201019 pandemic and subsequent infection surges. Comparisons were made with PD patients without a positive SARS\u2010CoV\u20102 test (defined by polymerase chain reaction test). Outcomes were post\u2010index date all\u2010cause mortality, major adverse cardiovascular events (MACE), altered mental status, fatigue, dyspnea, headache, psychosis, dementia, depression, anxiety, dysphagia, falls, and orthostatic hypotension. Changes in Levodopa prescriptions were also tabulated. Adjusted hazard ratios (aHR) were computed accounting for competing risks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PD patients with COVID\u201019 had similar demographics but a higher prevalence of pre\u2010existing comorbidities compared to PD patients without COVID\u201019. PD patients with COVID\u201019 had greater risk of mortality (aHR\u2009=\u20091.58 [95% CI: 1.03, 2.41]), MACE (aHR\u2009=\u20091.57 [1.19, 2.07]), dyspnea, fatigue, and fall compared to PD patients without COVID\u201019. Levodopa dose adjustment was higher post\u2010infection in the COVID\u201019 cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among PD patients, COVID\u201019 was associated with a higher risk of adverse long\u2010term outcomes. PD patients who survive COVID\u201019 may benefit from heightened clinical awareness and close follow\u2010up. Findings highlight the need to improve post\u2010COVID care for PD patients to mitigate disease progression and maintain quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70013","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T04:54:31Z","timestamp":1746593671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Impact of\n                    <scp>COVID<\/scp>\n                    \u201019 on long\u2010term outcomes in Parkinson's disease"],"prefix":"10.1111","volume":"32","author":[{"given":"Roham","family":"Hadidchi","sequence":"first","affiliation":[{"name":"Department of Radiology Albert Einstein College of Medicine and Montefiore Medical Center  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Al\u2010Ani","sequence":"additional","affiliation":[{"name":"Department of Radiology Albert Einstein College of Medicine and Montefiore Medical Center  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Piskun","sequence":"additional","affiliation":[{"name":"Department of Radiology Albert Einstein College of Medicine and Montefiore Medical Center  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Pakan","sequence":"additional","affiliation":[{"name":"Department of Radiology Albert Einstein College of Medicine and Montefiore Medical Center  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie S.","family":"Duong","sequence":"additional","affiliation":[{"name":"Department of Radiology Albert Einstein College of Medicine and Montefiore Medical Center  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Jamil","sequence":"additional","affiliation":[{"name":"Department of Radiology Albert Einstein College of Medicine and Montefiore Medical Center  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Albert Einstein College of Medicine and Montefiore Medical Center  Bronx New York USA"},{"name":"Department of Surgery Beth Israel Deaconess Medical Center and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonya","family":"Henry","sequence":"additional","affiliation":[{"name":"Department of Radiology Albert Einstein College of Medicine and Montefiore Medical Center  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine W.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Neurology Stony Brook University Renaissance School of Medicine  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6403-2827","authenticated-orcid":false,"given":"Tim Q.","family":"Duong","sequence":"additional","affiliation":[{"name":"Department of Radiology Albert Einstein College of Medicine and Montefiore Medical Center  Bronx New York USA"},{"name":"Center for Health and Data Innovation Albert Einstein College of Medicine and Montefiore Medical Center  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2278"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12603"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.09.052"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.101019"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.1914"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17709"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51350"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-021-01130-1"},{"key":"e_1_2_9_10_1","article-title":"Long\u2010term respiratory and neurological sequelae of COVID\u201019","volume":"26","author":"Wang F","year":"2020","journal-title":"Med Sci Monit"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103821"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104487"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.21174"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2022-003257"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.12.020"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01214-4"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-022-02590-9"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.103985"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.102915"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.104715"},{"key":"e_1_2_9_21_1","first-page":"342","article-title":"COVID\u201019 has no impact on disease activity, progression and cognitive performance in people with multiple sclerosis: a 2\u2010year study","volume":"95","author":"Montini F","year":"2023","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15477"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.105031"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2022.06.020"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200089"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.103946"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2024.105613"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.279222"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lana.2021.100041"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-22741-9"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-021-01646-1"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfad020"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15120"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.14058"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13010119"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e15277"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.798897"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004263"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-58430-y"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0303151"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15900"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12921"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2023.105892"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27492"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f61311"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.12.011"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05373-1"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01689-3"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-0360-5"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-024-00855-2"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27461"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1590\/1980-5764-dn-2021-0019"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00170-4"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2018.33.e300"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2019.09.002"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.3892\/mi.2023.83"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2024.02.041"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-202249"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/npjparkd.2015.14"},{"issue":"12","key":"e_1_2_9_60_1","first-page":"4535","article-title":"COVID\u201019 and neurodegenerative diseases","volume":"26","author":"Fu YW","year":"2022","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14703"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29116"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-023-03726-9"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14912"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-202038"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0704-09.2009"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2017-001650"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12670"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/6272982"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prdoa.2023.100194"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13020199"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T08:01:42Z","timestamp":1748332902000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":70,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/ene.70013"],"URL":"https:\/\/doi.org\/10.1111\/ene.70013","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70013"}}