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CR was operationalized via educational attainment (in years). Moderation models were run on each subscale of the cognitive section of the ECAS and on the ECAS\u2010CI by addressing ALSFRS\u2010R as the predictor and education as the moderator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Education was associated with both the ALSFRS\u2010R and all the cognitive subscales of the ECAS, while not with the ECAS\u2010CI. As to moderation models, a significant <jats:italic>Education<\/jats:italic>*<jats:italic>ALSFRS\u2010R<\/jats:italic> interaction was detected solely with regard to the ECAS\u2010Executive\u2014with its simple slope\u2010based decomposition revealing that higher ALSFRS\u2010R scores were associated with higher scores on the ECAS\u2010Executive for patients with low (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and average (<jats:italic>p<\/jats:italic>\u2009=\u20090.007), while not high, levels of education.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Education seems to moderate the association between motor involvement and executive status in ALS patients without dementia, thus possibly exerting a protective role towards both motor function and cognition in this 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