{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:14:49Z","timestamp":1790511289065,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Temporal lobe epilepsy (TLE) can lead to structural brain abnormalities, with thalamus atrophy being the most common extratemporal alteration. This study used probabilistic tractography to investigate the structural connectivity between individual thalamic nuclei and the hippocampus in TLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010six TLE patients who underwent pre\u2010surgical 3 Tesla magnetic resonance imaging (MRI) and 18 healthy controls were enrolled in this study. Patients were subdivided into TLE with HS (TLE\u2010HS) and MRI\u2010negative TLE (TLE\u2010MRneg). Tractography and whole brain segmentation, including thalamus parcellation, were performed to determine the number of streamlines per mm<jats:sup>3<\/jats:sup> between the thalamic nuclei and hippocampus. Connectivity strength and volume of regions were correlated with clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The volume of the entire thalamus ipsilateral to seizure onset was significantly decreased in TLE\u2010HS compared to controls (Mann\u2013Whitney\u2010<jats:italic>U<\/jats:italic> test: <jats:italic>p<\/jats:italic><jats:sub>FDR<\/jats:sub> &lt;\u20090.01) with the anterior thalamic nuclei (ANT) as important contributor. Furthermore, decreased ipsilateral connectivity strength between the hippocampus and ANT was detected in TLE\u2010HS (<jats:italic>p<\/jats:italic><jats:sub>FDR<\/jats:sub> &lt;\u20090.01) compared to TLE\u2010MRneg and controls which correlated negatively with the duration of epilepsy (<jats:italic>\u03c1<\/jats:italic>\u2009=\u2009\u22120.512, <jats:italic>p<\/jats:italic>\u2009=\u20090.025) and positively with seizure frequency (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.603, <jats:italic>p<\/jats:italic>\u2009=\u20090.006). Moreover, ANT volume correlated negatively with epilepsy duration in TLE\u2010HS (<jats:italic>\u03c1<\/jats:italic>\u2009=\u2009\u22120.471, <jats:italic>p<\/jats:italic>\u2009=\u20090.042).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ANT showed atrophy and decreased connectivity in TLE\u2010HS, which correlated with epilepsy duration and seizure frequency. Understanding the dynamics of epileptogenic networks has the potential to shed light on surgery\u2010resistant epilepsy and refine the selection process for ideal neurosurgical candidates, consequently enhancing post\u2010surgical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.70040","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T09:01:17Z","timestamp":1736586077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Decreased Structural Connectivity Between Thalamic Nuclei and Hippocampus in Temporal Lobe Epilepsy\u2014A Diffusion Tensor Imaging\u2010Based Study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4190-7277","authenticated-orcid":false,"given":"Mehmet S.","family":"Yildirim","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Medical University of Vienna  Vienna Austria"},{"name":"Developmental and Interventional Neuroimaging Lab (DINLAB), Department of Biomedical Imaging and Image\u2010Guided Therapy Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radheshyam","family":"Stepponat","sequence":"additional","affiliation":[{"name":"Developmental and Interventional Neuroimaging Lab (DINLAB), Department of Biomedical Imaging and Image\u2010Guided Therapy Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4573-7666","authenticated-orcid":false,"given":"Florian Ph. 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