{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T01:17:56Z","timestamp":1773969476212,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epileptiform activity, including status epilepticus (SE), occurs in up to one\u2010third of comatose survivors of cardiac arrest and may predict poor outcome. The relationship between SE and hypoxic\u2013ischemic brain injury (HIBI) is not established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a single\u2010center retrospective study on consecutive patients with post\u2010anoxic super\u2010refractory SE. HIBI was graded as non\u2010widespread (group 1) or widespread (group 2) by qualitative analysis of DWI\/ADC and T2w\u2010FLAIR. Between\u2010group differences in the rate of poor neurological outcome at 6\u2009months (primary outcome), SE resolution and consciousness recovery before discharge, and mortality at 6\u2009months (secondary outcomes) were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From January 2011 to February 2023, 40 patients were included. HIBI was widespread in 45% of patients and non\u2010widespread in 55%. The rate of poor neurological outcome at 6\u2009months was 27% in group 1 and 83% in group 2 (OR 12.8, CI 95% [2.5\u201364.3], <jats:italic>p<\/jats:italic>\u2009=\u20090.002). The rate of consciousness recovery before discharge was 73% in group 1 versus 22% in group 2 (OR 8.8, CI 95% [1.9\u201340.3], <jats:italic>p<\/jats:italic>\u2009=\u20090.005). SE resolved in 95% of patients in group 1 versus 67% in group 2 (OR 10.5, CI 95% [1.1\u201397.9], <jats:italic>p<\/jats:italic>\u2009=\u20090.039). Mortality rate at 6\u2009months was 27% in group 1 versus 50% in group 2 (OR 0.4, CI 95% [0.1\u20131.9], <jats:italic>p<\/jats:italic>\u2009=\u20090.303).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with widespread HIBI had higher odds of poor outcome at 6\u2009months, lower probability of SE resolution and of consciousness recovery before discharge compared to those with non\u2010widespread HIBI. Mortality at 6\u2009months did not differ significantly between the two groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.70045","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T12:23:04Z","timestamp":1737030184000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic Value of Signal Abnormalities on Brain <scp>MRI<\/scp> in Post\u2010Anoxic Super\u2010Refractory Status Epilepticus: A Single\u2010Center Retrospective Study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6201-1536","authenticated-orcid":false,"given":"Susanna","family":"Diamanti","sequence":"first","affiliation":[{"name":"Epilepsy Center, Department of Neurology Fondazione IRCCS San Gerardo Dei Tintori  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9966-9892","authenticated-orcid":false,"given":"Francesco","family":"Pasini","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Department of Neurology Fondazione IRCCS San Gerardo Dei Tintori  Monza Italy"},{"name":"Department of Medicine and Surgery University of Milano\u2010Bicocca  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Capraro","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit Fondazione IRCCS San Gerardo Dei Tintori  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirko","family":"Patassini","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit Fondazione IRCCS San Gerardo Dei Tintori  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0279-0128","authenticated-orcid":false,"given":"Elisa","family":"Bianchi","sequence":"additional","affiliation":[{"name":"IRCCS Mario Negri Institute for Pharmacological Research  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Pozzi","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Fondazione IRCCS San Gerardo Dei Tintori  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Normanno","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Fondazione IRCCS San Gerardo Dei Tintori  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Coppo","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Fondazione IRCCS San Gerardo Dei Tintori  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Remida","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit Fondazione IRCCS San Gerardo Dei Tintori  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonello","family":"Avalli","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Fondazione IRCCS San Gerardo Dei Tintori  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Ferrarese","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Department of Neurology Fondazione IRCCS San Gerardo Dei Tintori  Monza Italy"},{"name":"Department of Medicine and Surgery University of Milano\u2010Bicocca  Milano Italy"},{"name":"Milan Center for Neuroscience  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Foti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Milano\u2010Bicocca  Milano Italy"},{"name":"Department of Intensive Care Fondazione IRCCS San Gerardo Dei Tintori  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9417-2748","authenticated-orcid":false,"given":"Simone","family":"Beretta","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Department of Neurology Fondazione IRCCS San Gerardo Dei Tintori  Monza Italy"},{"name":"Department of Medicine and Surgery University of Milano\u2010Bicocca  Milano Italy"},{"name":"Milan Center for Neuroscience  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010011\u20109565\u20100"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2012.02.015"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2016.10.024"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010021\u201006368\u20104"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2115998"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2017.03.005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2016.10.021"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.08.005"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2015.04.043"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2014.00039"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000343006.60851.62"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006615"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2018.09.012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(16)30137\u20105"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13121"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14016"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000806"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000547"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.58245"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.541782.AD"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7441.702"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1970.10481076"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12143"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000013708.54623.de"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.632943"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2017.06.245"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017162161"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010014\u20109953\u20103"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31823fcd61"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010017\u20101670\u20109"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000013301"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.2340"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2014.11.031"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(18)30027\u20109"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2020.01.014"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002462"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13202"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/35002090"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2015.06.078"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1456"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000013297"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010023\u201001688\u20103"},{"issue":"8","key":"e_1_2_9_44_1","first-page":"1561","article-title":"MR Imaging in Comatose Survivors of Cardiac Resuscitation","volume":"22","author":"Wijdicks E. F.","year":"2001","journal-title":"AJNR. American Journal of Neuroradiology"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T05:11:18Z","timestamp":1737954678000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/ene.70045"],"URL":"https:\/\/doi.org\/10.1111\/ene.70045","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70045"}}