{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:47:16Z","timestamp":1763142436885,"version":"3.41.2"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients diagnosed with optic neuritis (ON) who did not fulfil the diagnostic criteria for multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMO\u2010SD), tested negative myelin oligodendrocyte glycoprotein immunoglobulin G and for which a systemic disease has been excluded are classified as having idiopathic ON (IDON).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a monocentric retrospective observational study. Inclusion criteria were as follows: patients with IDON, absence of an alternative diagnosis during the first 2\u2009years, follow\u2010up of at least 5\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010six patients were included. After a median follow\u2010up of 9\u2009years, a diagnosis of IDON was retained for 77.8% (<jats:italic>n<\/jats:italic>\u2009=\u200928) of patients, whereas 22.2% (<jats:italic>n<\/jats:italic>\u2009=\u20098) converted to an alternative diagnosis after a median of 6\u2009years. Four patients converted to MS, two to clinically isolated syndrome and two to seronegative NMO\u2010SD. Among the 28 patients who remained diagnosed with IDON, 42.9% (<jats:italic>n<\/jats:italic>\u2009=\u200912) experienced recurrent ON, occurring mostly (90%) within the first 5\u2009years of the disease. Maintenance therapy was initiated in 10 of the 12 patients, among whom 6 patients had no recurrence under treatment. For the 28 patients who remained with IDON, the final best corrected visual acuity (BCVA) was variable. Respectively, 35.7% and 25.9% of patients had a BCVA inferior to 0.5 and 0.2, whereas 50% recovered a final BCVA of 10\/10.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A significant proportion of the cohort converted to an alternative diagnosis after 2\u2009years, encouraging an extended follow\u2010up of IDON patients. Maintenance therapies were often effective in case of recurrent ON.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.70067","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T05:20:05Z","timestamp":1740028805000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010Term Outcome and Prognosis of Idiopathic Optic Neuritis: A Cohort Study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4531-5174","authenticated-orcid":false,"given":"Benjamin","family":"Leger","sequence":"first","affiliation":[{"name":"Department of Neurology H\u00f4pital Fondation Adolphe de Rothschild  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5170-5818","authenticated-orcid":false,"given":"Antoine","family":"Gueguen","sequence":"additional","affiliation":[{"name":"Department of Neurology H\u00f4pital Fondation 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