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This study addresses this gap by adding innovative multivariate pattern analysis (MVPA) to traditional univariate analysis of functional magnetic resonance imaging (fMRI) data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from 18 M\u2010D patients and 18 age\u2010matched healthy volunteers who performed a finger tapping fMRI task were analyzed. Whole\u2010brain univariate and searchlight (MVPA) analysis with varying hemodynamic response function (HRF) delays were employed to examine brain responses associated with the visually guided motor task.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Distinguishing response patterns between M\u2010D patients and healthy volunteers revealed significant response reductions in the putamen, insula, and visual cortex. Compared to univariate analysis, searchlight analysis was more sensitive for brain activity patterns associated with finger tapping in both M\u2010D patients and healthy volunteers. At short HRF delays, increased (pre)motor cortical responses were evident in M\u2010D patients, whereas such responses emerged at a later HRF delay in healthy volunteers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The task\u2010related effects observed in M\u2010D patients support the involvement of the basal ganglia\u2010thalamo\u2010cortical network. Notably, cerebellar involvement was not strongly implicated in our study. We postulate that inherent deficits in the putamen trigger either premature or downstream compensatory (motor) cortical effects. The potential involvement of the visual cortex in the M\u2010D pathophysiology is new, but its role has been suggested by a previous study investigating visual sensory processing in\n                      <jats:italic>SGCE<\/jats:italic>\n                      gene\u2010positive M\u2010D patients. Our findings, including the innovative searchlight method, pave the way for further studies investigating the complex interplay between brain regions and networks and their role in M\u2010D pathogenesis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70085","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T04:01:42Z","timestamp":1744430502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multivariate Pattern Analysis of\n                    <scp>fMRI<\/scp>\n                    Reveals Striato\u2010Cortical Network Changes in Myoclonus\u2010Dystonia"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6344-7323","authenticated-orcid":false,"given":"Ramesh S.","family":"Marapin","sequence":"first","affiliation":[{"name":"Department of Neurology, University Medical Center Groningen University of Groningen  Groningen the Netherlands"},{"name":"UMCG Expertise Center Movement Disorders Groningen University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6568-5739","authenticated-orcid":false,"given":"Bauke M.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Medical Center Groningen University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remco J.","family":"Renken","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elze R.","family":"Timmers","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Medical Center Groningen University of Groningen  Groningen the Netherlands"},{"name":"UMCG Expertise Center Movement Disorders Groningen University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5783-571X","authenticated-orcid":false,"given":"Marina A. 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