{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:31:01Z","timestamp":1753878661833,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neuropathies associated with IgA monoclonal gammopathy are poorly understood, and the interpretation of the presence of such gammopathy in a patient with neuropathy may be challenging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The neurological and hematological features of all patients newly diagnosed with IgA gammopathy by immunofixation in our center from January 2016 to December 2020 were retrospectively analyzed. Patients with neuropathy were identified through the medical records. The etiology was reviewed by two neurologists and classified into three groups: (i) IgA\u2010related neuropathies, (ii) IgA\u2010unrelated neuropathies with an identified alternative etiology, and (iii) neuropathies of uncertain relationship with IgA (NURIA) based on a negative extensive work\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 585 patients with IgA gammopathy, 79 had neuropathy (14%). Neuropathy was IgA\u2010related in 10 patients (13%): eight AL amyloidosis and two POEMS. In this group, the core features were neuropathic pain, autonomic dysfunction, fatigue or weight loss, and a lambda light chain. IgA\u2010unrelated neuropathies were more frequent (<jats:italic>N<\/jats:italic>\u2009=\u200964, 81%), encompassing mainly chemotherapy\u2010induced (<jats:italic>N<\/jats:italic>\u2009=\u200934) and diabetic (<jats:italic>N<\/jats:italic>\u2009=\u200915) neuropathies. Five patients (6%) were classified as NURIA: four had mild sensory\u2010predominant length\u2010dependent axonal neuropathy, and one had severe, progressive, motor\u2010predominant axonal neuropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with IgA gammopathy, neuropathies have a low prevalence and a wide etiological spectrum. AL amyloidosis and POEMS syndrome are rare but crucial to identify, as disease\u2010modifying treatments are available. Future studies should help better characterize the rare cases of neuropathy with an uncertain relationship to IgA gammopathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.70087","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T09:24:20Z","timestamp":1739957060000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and Spectrum of Neuropathies in a Cohort of 585 Patients With Immunoglobulin A Monoclonal Gammopathy"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9806-375X","authenticated-orcid":false,"given":"Valentine","family":"Perrain","sequence":"first","affiliation":[{"name":"D\u00e9partement de Neurologie AP\u2010HP, H\u00f4pital Henri Mondor  Cr\u00e9teil 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Creteil University (UPEC)  Creteil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Pascal","family":"Lefaucheur","sequence":"additional","affiliation":[{"name":"Faculty of Health, UR 4391 (ENT Team) Paris Est Creteil University (UPEC)  Creteil France"},{"name":"D\u00e9partement de Neurophysiologie Clinique AP\u2010HP, H\u00f4pital Henri Mondor  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2514-6148","authenticated-orcid":false,"given":"Thierry","family":"Gendre","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Neurologie AP\u2010HP, H\u00f4pital Henri Mondor  Cr\u00e9teil France"},{"name":"AP\u2010HP, Reference Center for Neuromuscular Diseases Nord\/Est\/Ile\u2010de\u2010France  Paris 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