{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:32Z","timestamp":1787014172320,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hereditary neuromuscular disorders (NMD) are associated with compromised bone health and elevated fracture risk, though data are largely lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to assess the prevalence and risk factors of fractures in hereditary NMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective study in a cohort of adult patients with diverse hereditary NMD, using data from electronic medical records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 469 patients, 505 fractures were recorded, with 5.5% of patients experiencing a fracture within the past year. In the 10\u2009years preceding study inclusion, 31.1% of all patients sustained at least one fracture. The fracture rate was 47.3\/1000 patient\u2010years. Fracture incidence was highest in the second decade of life and the first five years after symptom onset. Fracture recurrence occurred in 25.6% over the next two years. Fractures were most prevalent in patients with Duchenne muscular dystrophy, myotonic dystrophy type 1\/2, and spinal muscular atrophy. Patients with Vignos scale 5\u20136 had the highest fracture risk. Major osteoporotic fractures accounted for 28.6%, and 71.3% were caused by low\u2010energy trauma. Long\u2010term complications of a fracture were present in 44.2%, with 9.0% losing ambulation. Osteoporosis was confirmed in 47.5% of DXA scans. In patients with a normal DXA scan, 66.7% experienced a subsequent fracture. Hip T\u2010scores declined with increasing Vignos scale (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Fracture risk factors included glucocorticoid use, alcohol abuse, recent falls, and previous emergency visits for falls (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This cohort exhibited a high prevalence of fractures and osteoporosis, emphasizing the need for regular bone health assessment and fracture prevention in hereditary NMD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70099","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T05:52:35Z","timestamp":1741758755000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fractures in Hereditary Neuromuscular Disorders: Frequency, Risk Factors, and Implications"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5168-6284","authenticated-orcid":false,"given":"Matthias","family":"Opsomer","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospitals Leuven  Leuven Belgium"},{"name":"Department of Neurosciences Laboratory for Muscle Diseases and Neuropathies, KU Leuven, and Leuven Brain Institute (LBI)  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4676-5119","authenticated-orcid":false,"given":"Louise","family":"Iterbeke","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Laboratory for Muscle Diseases and Neuropathies, KU Leuven, and Leuven Brain Institute (LBI)  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Borghs","sequence":"additional","affiliation":[{"name":"Centre for Metabolic Bone Diseases University Hospitals Leuven  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