{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:51:22Z","timestamp":1791204682087,"version":"4.2.0"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:00:00Z","timestamp":1743811200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Lumbar puncture (LP) is a routine clinical procedure and, in some cases, is repeatedly performed for diagnostic or therapeutic reasons. The impact of repeated LP on cerebrospinal fluid (CSF) findings is not clear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate whether repeated LP is associated with reactive pleocytosis and disruption of blood\u2013CSF barrier function and to determine the role of interval between repeated LP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with non\u2010inflammatory neurological disease (NIND) and at least two consecutive LP were included. Longitudinal changes in CSF white blood cell count (WBC), CSF total protein (TP), and CSF\/serum albumin quotient (Q\n                      <jats:sub>alb<\/jats:sub>\n                      ) were assessed depending on the time interval between the LP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 73 patients with a median age of 35\u2009years (25th\u201375th percentile: 25\u201345) and a female predominance of 75% had second LP after 6 (3\u201319) days. Twenty (27%) patients developed pleocytosis with an increase of WBC count to 8\/\u03bcl (6\u201315) with a maximum of 30\/\u03bcl. Patients with pleocytosis had the follow\u2010up LP significantly earlier than patients without pleocytosis, 3.5 (3\u20137) versus 7 (3\u201328) days. The majority of patients (90%) with CSF pleocytosis had the second LP within 10\u2009days. Further repeated LP in a subgroup of patients revealed similar findings. CSF TP and Q\n                      <jats:sub>alb<\/jats:sub>\n                      slightly increased in patients with pleocytosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Mild \u201creactive\u201d CSF pleocytosis occurred in approximately one\u2010third of patients after repeated LP, mostly when performed within 10\u2009days.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70117","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T19:32:03Z","timestamp":1743881523000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Reactive Pleocytosis After Repeated Lumbar Puncture\u2014Implications for Clinical Practice"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3081-854X","authenticated-orcid":false,"given":"Martin","family":"Schmidauer","sequence":"first","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7970-5349","authenticated-orcid":false,"given":"Fabian","family":"F\u00f6ttinger","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Vienna  Vienna Austria"},{"name":"Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2755-2043","authenticated-orcid":false,"given":"Klaus","family":"Berek","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck  Innsbruck 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