{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:53:36Z","timestamp":1775793216532,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute respiratory insufficiency (ARI) is considered a serious life\u2010threatening complication after ischaemic stroke. The aim of this study was to identify the most common aetiologies of ARI after stroke and their association with patients' outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study was conducted at the University Hospital Bonn, involving patients with acute ischaemic stroke who underwent chest CT scans for ARI between 2017 and 2022. We collected clinical and demographic data, laboratory parameters, vital signs, as well as outcome parameters. CT scans were reviewed by a radiologist. The dataset was analysed to identify the most frequent aetiologies and their associations to outcome parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 236 patients with a median age of 75\u2009years and a median NIHSS score of 11. In\u2010hospital mortality accounted for 30.5%. The most frequent pulmonary conditions on CT, in order of prevalence, included bronchitis\/bronchiolitis (66.1%), atelectasis (66.1%), pleural effusion (60.6%), pneumonia (53%), pulmonary oedema (37.3%), and pulmonary artery embolism (27.5%). Bronchitis\/bronchiolitis was an independent risk factor for mortality (OR\u2009=\u20093.17, 95% CI: 1.11\u20138.79, <jats:italic>p<\/jats:italic>\u2009=\u20090.03). A higher number of pulmonary conditions decreased the likelihood of discharge to home, and non\u2010survivors had worse vital\/laboratory parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We identified six key pulmonary aetiologies of ARI after ischaemic stroke, with bronchitis\/bronchiolitis notably linked to in\u2010hospital mortality in our study cohort. An increased number of these acute pulmonary conditions decreased the likelihood of discharge to home. Early chest CT\/CT\u2010angiography may help to identify patients at high risk for in\u2010hospital mortality and to initiate appropriate treatment early.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.70125","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T05:51:19Z","timestamp":1743054679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Aetiology of Acute Respiratory Insufficiency in Patients With Ischaemic Stroke Studied by Chest <scp>CT<\/scp> Scan"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6367-8742","authenticated-orcid":false,"given":"Omid","family":"Shirvani","sequence":"first","affiliation":[{"name":"Department of Vascular Neurology University Hospital Bonn  Bonn Germany"},{"name":"German Center for Neurodegenerative Diseases  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Fischbein","sequence":"additional","affiliation":[{"name":"Department of Vascular Neurology University Hospital Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Bendella","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology University Hospital Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piergiorgio","family":"Profico","sequence":"additional","affiliation":[{"name":"Department of Vascular Neurology University Hospital Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Dorn","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology University Hospital Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabor C.","family":"Petzold","sequence":"additional","affiliation":[{"name":"Department of Vascular Neurology University Hospital Bonn  Bonn Germany"},{"name":"German Center for Neurodegenerative Diseases  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1182-705X","authenticated-orcid":false,"given":"Sebastian","family":"St\u00f6sser","sequence":"additional","affiliation":[{"name":"Department of Vascular Neurology University Hospital Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2021.07.027"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.3.415"},{"key":"e_1_2_13_4_1","first-page":"26111886","article-title":"Stroke\u2010Associated Pneumonia: Risk Factors, Mechanisms, and Interventions","author":"May B.","year":"2022","journal-title":"Neurology Advisor"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-019-04163-0"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02177-0"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.009617"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2012.00864.x"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v17i1.17"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445299"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/2396987319851335"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2012.042"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.176.6.1761415"},{"issue":"11","key":"e_1_2_13_14_1","article-title":"Stroke and Pneumonia: Mechanisms, Risk Factors, Management, and Prevention","volume":"13","author":"Grossmann I.","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-005-0037-9"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00435\u20102019"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.561019"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000151636"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.07.001"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2010.09.006"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000440733"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24262"},{"key":"e_1_2_13_23_1","unstructured":"K.Grott S.Chauhan D. 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