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The aim of this Italian multisite prospective longitudinal study was to identify valuable predictors of the complete recovery of consciousness (emergence from Minimally Conscious State, eMCS) at 3\u2009months (T1) from the admission in intensive rehabilitation units (IRUs) in pDoC (T0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with Unresponsive Wakefulness Syndrome (UWS) or MCS admitted within 3\u2009months of injury to 4 Italian IRUs were included. Demographic, clinical, and neurophysiological data were collected at T0, and a clinical diagnosis of consciousness (UWS, MCS\u2212, MCS+) was established at T0 and T1 using the Coma Recovery Scale\u2010Revised (CRS\u2010R).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred forty\u2010three patients were initially included and 131 completed follow\u2010ups at T1: (76 males; median age: 69\u2009years [IQR\u2009=\u200923]; VS\/UWS: 51, MCS\u2212: 29, MCS+: 51; etiology: 33 traumatic, 14 anoxic, 24 ischemic, 55 hemorrhagic, 5 other; median time post\u2010injury: 40\u2009days [IQR\u2009=\u200923]). At T1, 77 patients were eMCS, and 10 improved their clinical diagnosis. Among the clinical and neurophysiological independent variables, a higher CRS\u2010R visual sub\u2010score and the presence of EEG reactivity to eye opening at T0 were the best independent predictors of eMCS. Out of 77 eMCS, 18 reached a moderate disability (Glasgow Outcome Scale Extended\u2010GOSE\u2009&gt;\u20094), while the others persisted with a severe disability (GOS\u2010E\u2009\u2264\u20094).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A multimodal assessment can help identify patients who achieve functionally relevant improvements and thus better support clinicians when communicating with caregivers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      registration number: NCT04495192\n                    <\/jats:p>\n                  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